PWAP_HALLA
ID PWAP_HALLA Reviewed; 134 AA.
AC P84811;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Perlwapin;
OS Haliotis laevigata (Smooth Australian abalone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Vetigastropoda; Lepetellida; Haliotoidea; Haliotidae; Haliotis.
OX NCBI_TaxID=36097;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, AND VARIANTS ASP-11;
RP GLY-12; ARG-12; GLY-TYR-13; ALA-15; ALA-22; ASP-26; ILE-86; VAL-101;
RP ALA-103; ALA-106; LEU-127 AND ASN-134.
RC TISSUE=Shell {ECO:0000269|PubMed:16861275};
RX PubMed=16861275; DOI=10.1529/biophysj.106.086108;
RA Treccani L., Mann K., Heinemann F., Fritz M.;
RT "Perlwapin, an abalone nacre protein with three four-disulfide core (whey
RT acidic protein) domains, inhibits the growth of calcium carbonate
RT crystals.";
RL Biophys. J. 91:2601-2608(2006).
CC -!- FUNCTION: Inhibits growth of calcium carbonate crystals. May inhibit
CC growth of certain crystallographic planes in the mineral phase of nacre
CC in the shell. {ECO:0000269|PubMed:16861275}.
CC -!- TISSUE SPECIFICITY: Nacreous layer of shell.
CC {ECO:0000269|PubMed:16861275}.
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DR AlphaFoldDB; P84811; -.
DR SMR; P84811; -.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 4.10.75.10; -; 3.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 3.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 2.
DR SUPFAM; SSF57256; SSF57256; 2.
DR PROSITE; PS51390; WAP; 3.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Repeat.
FT CHAIN 1..134
FT /note="Perlwapin"
FT /id="PRO_0000248608"
FT DOMAIN 2..45
FT /note="WAP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 46..89
FT /note="WAP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 90..132
FT /note="WAP 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 8..34
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 17..38
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 21..33
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 27..42
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 51..77
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 59..82
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 64..76
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 70..85
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 94..121
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 104..124
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 108..120
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 114..128
FT /evidence="ECO:0000250|UniProtKB:Q9N0L8,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT VARIANT 11
FT /note="G -> D"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 12
FT /note="P -> G"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 12
FT /note="P -> R"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 13
FT /note="Y -> GY"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 15
FT /note="R -> A"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 22
FT /note="H -> A"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 26
FT /note="E -> D"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 86
FT /note="Y -> I"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 101
FT /note="A -> V"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 103
FT /note="V -> A"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 106
FT /note="I -> A"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 127
FT /note="R -> L"
FT /evidence="ECO:0000269|PubMed:16861275"
FT VARIANT 134
FT /note="D -> N"
FT /evidence="ECO:0000269|PubMed:16861275"
SQ SEQUENCE 134 AA; 14528 MW; 6674C0F28485C79A CRC64;
YGPNLPGCPP GPYPRICARY CHSDRECKAG YYCCNTGCLN ICVPKPKPGL CPAIRPGPCK
GNVCSNDQDC PGNQKCCGKP GCRRCYRPEK PGSCPPRKYD AGVCVIYCVG DFDCPGNEKC
CGSCPRRCEK PCFD
