ID   ATP6_CAEEL              Reviewed;         199 AA.
AC   P24888;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   06-JUL-2016, sequence version 2.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=ATP synthase subunit a;
DE   AltName: Full=F-ATPase protein 6;
GN   Name=atp-6 {ECO:0000312|WormBase:MTCE.12};
GN   ORFNames=MTCE.12 {ECO:0000312|WormBase:MTCE.12};
OS   Caenorhabditis elegans.
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=1551572; DOI=10.1093/genetics/130.3.471;
RA   Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.;
RT   "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and
RT   Ascaris suum.";
RL   Genetics 130:471-498(1992).
CC   -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC       Complex V) produces ATP from ADP in the presence of a proton gradient
CC       across the membrane which is generated by electron transport complexes
CC       of the respiratory chain. F-type ATPases consist of two structural
CC       domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC       - containing the membrane proton channel, linked together by a central
CC       stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC       catalytic domain of F(1) is coupled via a rotary mechanism of the
CC       central stalk subunits to proton translocation. Key component of the
CC       proton channel; it may play a direct role in the translocation of
CC       protons across the membrane.
CC   -!- SUBUNIT: Subunit of the F-type ATPase which has 2 components, CF(1)
CC       - the catalytic core - and CF(0) - the membrane proton channel.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}.
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DR   EMBL; X54252; CAA38154.1; -; Genomic_DNA.
DR   RefSeq; NP_006956.1; NC_001328.1.
DR   AlphaFoldDB; P24888; -.
DR   SMR; P24888; -.
DR   STRING; 6239.MTCE.12; -.
DR   PeptideAtlas; P24888; -.
DR   EnsemblMetazoa; MTCE.12.1; MTCE.12.1; WBGene00010960.
DR   GeneID; 2565704; -.
DR   KEGG; cel:ATP6; -.
DR   CTD; 4508; -.
DR   WormBase; MTCE.12; CE35346; WBGene00010960; atp-6.
DR   eggNOG; KOG4665; Eukaryota.
DR   HOGENOM; CLU_1373333_0_0_1; -.
DR   InParanoid; P24888; -.
DR   OrthoDB; 1095315at2759; -.
DR   PRO; PR:P24888; -.
DR   Proteomes; UP000001940; Mitochondrion.
DR   Bgee; WBGene00010960; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015986; P:proton motive force-driven ATP synthesis; IBA:GO_Central.
DR   Gene3D; 1.20.120.220; -; 1.
DR   InterPro; IPR000568; ATP_synth_F0_asu.
DR   InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR   InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR   InterPro; IPR035908; F0_ATP_A_sf.
DR   PANTHER; PTHR11410; PTHR11410; 1.
DR   Pfam; PF00119; ATP-synt_A; 1.
DR   SUPFAM; SSF81336; SSF81336; 1.
DR   PROSITE; PS00449; ATPASE_A; 1.
PE   3: Inferred from homology;
KW   ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..199
FT                   /note="ATP synthase subunit a"
FT                   /id="PRO_0000082101"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   199 AA;  23039 MW;  CCDB65BAD802A945 CRC64;
     MNQVYFLDIF MFVFVLQFLF YFKESMLNTL VKKFLNSLVG VFSYTNTLPL SSVISIFTFI
     VLLTCCFGGY FTYSFCPCGM VEFTFVYAAV AWLSTLLTFI SSEKFSVYMS KPGDTYLKTL
     SMLLIEIVSE FSRPLALTVR LTVNITVGHL VSMMLYQGLE LSMGDQYIWL SILAIMMECF
     VFFIQSYIFS RLIFLYLNE