ID   ATP5S_MACFA             Reviewed;         200 AA.
AC   Q4R5S4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=ATP synthase subunit s, mitochondrial;
DE   AltName: Full=ATP synthase-coupling factor B;
DE            Short=FB;
DE   AltName: Full=Distal membrane arm assembly complex 2-like protein {ECO:0000250|UniProtKB:Q99766};
DE   AltName: Full=Mitochondrial ATP synthase regulatory component factor B;
DE   Flags: Precursor;
GN   Name=DMAC2L; Synonyms=ATP5S; ORFNames=QtsA-21272;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in regulation of mitochondrial membrane ATP
CC       synthase. Necessary for H(+) conduction of ATP synthase. Facilitates
CC       energy-driven catalysis of ATP synthesis by blocking a proton leak
CC       through an alternative proton exit pathway.
CC       {ECO:0000250|UniProtKB:P22027}.
CC   -!- SUBUNIT: Homotetramer. Associates with ATP synthase.
CC       {ECO:0000250|UniProtKB:P22027}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P22027}.
CC       Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22027}.
CC   -!- SIMILARITY: Belongs to the ATP synthase subunit s family.
CC       {ECO:0000305}.
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DR   EMBL; AB169469; BAE01551.1; -; mRNA.
DR   AlphaFoldDB; Q4R5S4; -.
DR   SMR; Q4R5S4; -.
DR   STRING; 9541.XP_005561258.1; -.
DR   PRIDE; Q4R5S4; -.
DR   eggNOG; KOG3864; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR026063; ATP5S/ATP5SL.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR13382:SF10; PTHR13382:SF10; 1.
PE   2: Evidence at transcript level;
KW   ATP synthesis; CF(0); Hydrogen ion transport; Ion transport;
KW   Leucine-rich repeat; Magnesium; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat; Transit peptide;
KW   Transport.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250|UniProtKB:P22027"
FT   CHAIN           26..200
FT                   /note="ATP synthase subunit s, mitochondrial"
FT                   /id="PRO_0000318693"
FT   REPEAT          62..87
FT                   /note="LRR 1"
FT                   /evidence="ECO:0000250|UniProtKB:P22027"
FT   REPEAT          88..116
FT                   /note="LRR 2"
FT                   /evidence="ECO:0000250|UniProtKB:P22027"
FT   REPEAT          117..141
FT                   /note="LRR 3"
FT                   /evidence="ECO:0000250|UniProtKB:P22027"
FT   REPEAT          142..173
FT                   /note="LRR 4"
FT                   /evidence="ECO:0000250|UniProtKB:P22027"
FT   REGION          1..61
FT                   /note="N-terminal domain"
FT                   /evidence="ECO:0000250|UniProtKB:P22027"
FT   BINDING         59
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250|UniProtKB:P22027"
FT   BINDING         93
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250|UniProtKB:P22027"
SQ   SEQUENCE   200 AA;  23140 MW;  E9A295EAD03B0A62 CRC64;
     MMLFGKVSQQ LCGIKKLPWS CDSRYFWGWL NAVFNKVDYD RIRDVGPDRA ASEWLLRCGA
     MVRYHGQERW QTDYNHLPTG PLDKYKIQAI DATNSCIMSI GFDHMVGLQH VEKIRLCKCH
     FIEDDCLLRL GQLENLQKSI LEMEIISCGN ITDKGIIASR HLRNLKYLLL SDLPGVREKE
     NLIQVFETAL PSLELKLQLK