ATP25_YEAST
ID ATP25_YEAST Reviewed; 612 AA.
AC Q03153; D6VZS1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=ATPase synthesis protein 25, mitochondrial;
DE AltName: Full=OLI1 mRNA stabilization factor;
DE Flags: Precursor;
GN Name=ATP25; OrderedLocusNames=YMR098C; ORFNames=YM6543.05C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16823961; DOI=10.1021/pr050477f;
RA Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT "Toward the complete yeast mitochondrial proteome: multidimensional
RT separation techniques for mitochondrial proteomics.";
RL J. Proteome Res. 5:1543-1554(2006).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18216280; DOI=10.1091/mbc.e07-08-0746;
RA Zeng X., Barros M.H., Shulman T., Tzagoloff A.;
RT "ATP25, a new nuclear gene of Saccharomyces cerevisiae required for
RT expression and assembly of the Atp9p subunit of mitochondrial ATPase.";
RL Mol. Biol. Cell 19:1366-1377(2008).
CC -!- FUNCTION: mRNA stabilization factor specific for the 0.95 kb OLI1 mRNA.
CC Also involved in OLI1 ring formation. {ECO:0000269|PubMed:18216280}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961,
CC ECO:0000269|PubMed:18216280}; Peripheral membrane protein
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961,
CC ECO:0000269|PubMed:18216280}; Matrix side {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:18216280}.
CC -!- MISCELLANEOUS: Present with 2430 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the ATP25 family. {ECO:0000305}.
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DR EMBL; Z49807; CAA89899.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09995.1; -; Genomic_DNA.
DR PIR; S55084; S55084.
DR RefSeq; NP_013816.1; NM_001182598.1.
DR AlphaFoldDB; Q03153; -.
DR SMR; Q03153; -.
DR BioGRID; 35273; 25.
DR IntAct; Q03153; 2.
DR MINT; Q03153; -.
DR STRING; 4932.YMR098C; -.
DR MaxQB; Q03153; -.
DR PaxDb; Q03153; -.
DR PRIDE; Q03153; -.
DR EnsemblFungi; YMR098C_mRNA; YMR098C; YMR098C.
DR GeneID; 855123; -.
DR KEGG; sce:YMR098C; -.
DR SGD; S000004704; ATP25.
DR VEuPathDB; FungiDB:YMR098C; -.
DR eggNOG; ENOG502RGZN; Eukaryota.
DR HOGENOM; CLU_487522_0_0_1; -.
DR InParanoid; Q03153; -.
DR OMA; KISDFMV; -.
DR BioCyc; YEAST:G3O-32798-MON; -.
DR PRO; PR:Q03153; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q03153; protein.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0140053; P:mitochondrial gene expression; IEA:InterPro.
DR GO; GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; IMP:SGD.
DR GO; GO:0048255; P:mRNA stabilization; IMP:SGD.
DR Gene3D; 3.30.460.10; -; 1.
DR InterPro; IPR040152; Atp25.
DR InterPro; IPR025210; ATP25_mRNA_stabil_dom.
DR InterPro; IPR043519; NT_sf.
DR PANTHER; PTHR28087; PTHR28087; 1.
DR Pfam; PF13929; mRNA_stabil; 1.
DR SUPFAM; SSF81301; SSF81301; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..14
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 15..612
FT /note="ATPase synthesis protein 25, mitochondrial"
FT /id="PRO_0000203288"
SQ SEQUENCE 612 AA; 70414 MW; CC0B89608796A24F CRC64;
MNKFCLLPFH GKRIGVANIP FTILFKKGPY FLHSHITAVY YSTKGKNDSH EQSRVSKKST
FTPLETPWYL RIVDNEKELM EGKKNNHHTM NKELEIPKTS PNSLRKIADL LTGKLGLDDF
LVFDLRKKSP NSVSAVNKLG DFMVICTARS TKHCHKSFLE LNKFLKHEFC SSAYVEGNFN
ERQESRRKRR LARKSNLSKL LGRSSECSAK DLNSEAWYMI DCRVDGIFVN ILTQRRRNEL
NLEELYAPEN EKSKFQNIDS GNVPTISGVN EISSNNNILL GLRRLAQQRR RYSTINPNGL
SNLRYFLQKE DFKGANKIIQ SSSGTETHNI RTLEHVKNTL KDLVGQERKV DVVQWKSLFD
EHSTFLTINQ SAAYWPLRLE YAILLNKADP QFYSDRVFLK DYLLLKKSLG QELIREDLIA
LLEMVLKTQH SSHSYFNLVK QNRVIIRALN LFKGLQTEDD GSVVYDEVVI SLLLNSMVAD
ERVKLRSLYE TIDHIFQTFG DKLTSGMIVS ILQNLAKIKD WNKLLQVWEA ITPTEGEGQD
KRPWNEFINV INQSGDSHVI SKIVNNGHLL WIRRLNVNVT PELCNSIKAL LKTAGMENST
LEEFLVRGTN NQ
