ID   PRP45_CANGA             Reviewed;         414 AA.
AC   Q6FIT9;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Pre-mRNA-processing protein 45;
GN   Name=PRP45; OrderedLocusNames=CAGL0M11814g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNW family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62835.1; -; Genomic_DNA.
DR   RefSeq; XP_449855.1; XM_449855.1.
DR   AlphaFoldDB; Q6FIT9; -.
DR   STRING; 5478.XP_449855.1; -.
DR   EnsemblFungi; CAG62835; CAG62835; CAGL0M11814g.
DR   GeneID; 2891250; -.
DR   KEGG; cgr:CAGL0M11814g; -.
DR   CGD; CAL0136955; CAGL0M11814g.
DR   VEuPathDB; FungiDB:CAGL0M11814g; -.
DR   eggNOG; KOG2441; Eukaryota.
DR   HOGENOM; CLU_006601_3_1_1; -.
DR   InParanoid; Q6FIT9; -.
DR   OMA; NGFTIAL; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:EnsemblFungi.
DR   InterPro; IPR017862; SKI-int_prot_SKIP.
DR   InterPro; IPR004015; SKI-int_prot_SKIP_SNW-dom.
DR   PANTHER; PTHR12096; PTHR12096; 1.
DR   Pfam; PF02731; SKIP_SNW; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..414
FT                   /note="Pre-mRNA-processing protein 45"
FT                   /id="PRO_0000084817"
FT   REGION          128..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..292
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  46265 MW;  0D5FFED34A2E435D CRC64;
     MSFSSLLPPP EHSPPDDVNS REVEIITKEH DFIVNALTKK EAVHSSNNNI GSFVGSQVAN
     FNDVIPLRQK DFYGVQAPLP TTQEIELCKV RTQEVVNRLL HKFTDKGKAG YQKDTRKITT
     GSRIITIESK RQDPLQPSRQ KNTSSKIVLP EDDETDTPIL HATDDAKSKR LTKEERAKWN
     IPAAVSSWKN PMGYTVGLKH RAAHGKKTGN VGSINNKVSD IVAALDETDQ EIREGIQQEN
     ELKRKQLKEE ERIKEEKLRA IAERSKIQTQ SSAVKKRGSR FEGGRHQNKK IKKEEPPIKS
     AAERLKELAY AQGREVSEKV ILGAAKATTT GTGANVHYDS RLFSKGANAA AKRSEEQVYD
     NPLFVQQEID SIYRVNAKSI DEANSVSASR YGPIQFTKAH SLDDKSTAKD EEET