ID   PRP39_SCHPO             Reviewed;         612 AA.
AC   O74970;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Pre-mRNA-processing factor 39;
GN   Name=prp39; ORFNames=SPBC4B4.09;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Function prior to stable branch point recognition by the U1
CC       snRNP particle to facilitate or stabilize the U1 snRNP/5'-splice site
CC       interaction. Has a direct role in the assembly or function of a
CC       catalytically active spliceosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRP39 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA19289.1; -; Genomic_DNA.
DR   PIR; T40481; T40481.
DR   RefSeq; NP_596426.1; NM_001022345.2.
DR   AlphaFoldDB; O74970; -.
DR   SMR; O74970; -.
DR   BioGRID; 277386; 13.
DR   STRING; 4896.SPBC4B4.09.1; -.
DR   iPTMnet; O74970; -.
DR   MaxQB; O74970; -.
DR   PaxDb; O74970; -.
DR   PRIDE; O74970; -.
DR   EnsemblFungi; SPBC4B4.09.1; SPBC4B4.09.1:pep; SPBC4B4.09.
DR   GeneID; 2540869; -.
DR   KEGG; spo:SPBC4B4.09; -.
DR   PomBase; SPBC4B4.09; -.
DR   VEuPathDB; FungiDB:SPBC4B4.09; -.
DR   eggNOG; KOG1258; Eukaryota.
DR   HOGENOM; CLU_007434_3_1_1; -.
DR   InParanoid; O74970; -.
DR   OMA; NYCAFKV; -.
DR   PhylomeDB; O74970; -.
DR   PRO; PR:O74970; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0000243; C:commitment complex; ISO:PomBase.
DR   GO; GO:0005685; C:U1 snRNP; IDA:PomBase.
DR   GO; GO:0071004; C:U2-type prespliceosome; ISO:PomBase.
DR   GO; GO:0000395; P:mRNA 5'-splice site recognition; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   SMART; SM00386; HAT; 7.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..612
FT                   /note="Pre-mRNA-processing factor 39"
FT                   /id="PRO_0000205757"
FT   REPEAT          158..191
FT                   /note="HAT 1"
FT   REPEAT          367..399
FT                   /note="HAT 2"
SQ   SEQUENCE   612 AA;  71247 MW;  9A9A9B5600E442B7 CRC64;
     MDYGDIYIAE ETEWDKYNRQ INKNPDDFDA WEGLVRASEH LEGGVGRNSS KQAINTLRSV
     YDRFLGKYPL LFGYWKKYAD FEFFVAGAEA SEHIYERGIA GIPHSVDLWT NYCAFKMETN
     GDANEVRELF MQGANMVGLD FLSHPFWDKY LEFEERQERP DNVFQLLERL IHIPLHQYAR
     YFERFVQVSQ SQPIQQLLPP DVLASIRADV TREPAKVVSA GSKQITVERG ELEIEREMRA
     RIYNIHLQIF QKVQLETAKR WTFESEIKRP YFHVKELDEA QLVNWRKYLD FEEVEGDFQR
     ICHLYERCLI TCALYDEFWF RYARWMSAQP DHLNDVSIIY ERASCIFASI SRPGIRVQYA
     LFEESQGNIA SAKAIYQSIL TQLPGNLEAV LGWVGLERRN APNYDLTNAH AVLRSIINEG
     KCNTGITEVL ITEDIKLVWK IEGDIELARN MFLQNAPALL DCRHFWISFL RFELEQPLNS
     KNYTEHHARV SNVMEMIRNK TRLPPRTIMD LTKLYMEYLC HQSNDPSVLQ EYLLIDRDVF
     GPFSVRESHW KKLDEGQDLK QVSTRLLSTN GHPGISVNEA KIKSGESPYE KYYRLQGVVE
     TVTSGVAANG SS