PRP39_MOUSE
ID PRP39_MOUSE Reviewed; 665 AA.
AC Q8K2Z2; Q8C1I4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 3.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Pre-mRNA-processing factor 39;
DE AltName: Full=PRP39 homolog;
GN Name=Prpf39;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Dendritic cell, Embryonic kidney, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K2Z2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K2Z2-2; Sequence=VSP_021498;
CC -!- SIMILARITY: Belongs to the PRP39 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE32419.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK017379; BAC25514.1; -; mRNA.
DR EMBL; AK154170; BAE32419.1; ALT_INIT; mRNA.
DR EMBL; AK168462; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC029153; AAH29153.1; -; mRNA.
DR PDB; 6G70; X-ray; 3.30 A; A/B=1-665.
DR PDBsum; 6G70; -.
DR AlphaFoldDB; Q8K2Z2; -.
DR SMR; Q8K2Z2; -.
DR STRING; 10090.ENSMUSP00000112953; -.
DR iPTMnet; Q8K2Z2; -.
DR PhosphoSitePlus; Q8K2Z2; -.
DR EPD; Q8K2Z2; -.
DR MaxQB; Q8K2Z2; -.
DR PaxDb; Q8K2Z2; -.
DR PeptideAtlas; Q8K2Z2; -.
DR PRIDE; Q8K2Z2; -.
DR ProteomicsDB; 291531; -. [Q8K2Z2-1]
DR ProteomicsDB; 291532; -. [Q8K2Z2-2]
DR UCSC; uc007nra.1; mouse. [Q8K2Z2-2]
DR MGI; MGI:104602; Prpf39.
DR eggNOG; KOG1258; Eukaryota.
DR InParanoid; Q8K2Z2; -.
DR PhylomeDB; Q8K2Z2; -.
DR ChiTaRS; Prpf39; mouse.
DR PRO; PR:Q8K2Z2; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8K2Z2; protein.
DR GO; GO:0000243; C:commitment complex; IBA:GO_Central.
DR GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR GO; GO:0000395; P:mRNA 5'-splice site recognition; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR SMART; SM00386; HAT; 7.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; mRNA processing; mRNA splicing;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..665
FT /note="Pre-mRNA-processing factor 39"
FT /id="PRO_0000259649"
FT REPEAT 107..139
FT /note="HAT 1"
FT REPEAT 141..173
FT /note="HAT 2"
FT REPEAT 181..216
FT /note="HAT 3"
FT REPEAT 218..251
FT /note="HAT 4"
FT REPEAT 331..363
FT /note="HAT 5"
FT REPEAT 365..397
FT /note="HAT 6"
FT REPEAT 402..434
FT /note="HAT 7"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 44
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86UA1"
FT VAR_SEQ 1..394
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_021498"
FT HELIX 79..88
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 93..106
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 109..122
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 127..139
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 143..156
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 161..173
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 181..197
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 204..216
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 220..230
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 238..250
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 254..257
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 260..273
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 296..334
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 351..363
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 367..379
FT /evidence="ECO:0007829|PDB:6G70"
FT TURN 380..383
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 385..397
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 402..411
FT /evidence="ECO:0007829|PDB:6G70"
FT TURN 412..414
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 419..432
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 436..449
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 453..465
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 469..482
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 486..502
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 507..521
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 525..537
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 542..555
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 562..577
FT /evidence="ECO:0007829|PDB:6G70"
FT HELIX 582..601
FT /evidence="ECO:0007829|PDB:6G70"
SQ SEQUENCE 665 AA; 77921 MW; AA438A555CE4B615 CRC64;
MQNSHMEEYR NSDNGSTGNS SEVAVVEHPD FSTEIMNVTE MEQSPDASPS AHASTEENEM
ANAVNLPVTE AEGDFPPEFE KFWKTVEMNP QDFTGWVYLL QYVEQENHLM AARKAFDKFF
VHYPYCYGYW KKYADLEKRH DNIKQSDEVY RRGLQAIPLS VDLWIHYINF LKETLEPGDQ
ETNTTIRGTF EHAVLAAGTD FRSDKLWEMY INWENEQGNL REVTAVYDRI LGIPTQLYSH
HFQRFKEHVQ NNLPRDLLTG EQFIQLRREL ASVNGHSGDD GPPGDDLPSG IEDISPAKLI
TEIENMRHRI IEIHQEMFNY NEHEVSKRWT FEEGIKRPYF HVKPLEKAQP KKNWKEYLEF
EIENGTHERV VVLFERCVIS CALYEEFWIK YAKYMENHSI EGVRHVFSRA CTVHLPKKPM
AHMLWAAFEE QQGNINEARI ILRTFEECVL GLAMVRLRRV SLERRHGNME EAEHLLQDAI
KNAKSNNESS FYAIKLARHL FKIQKNLPKS RKVLLEAIEK DKENTKLYLN LLEMEYSCDL
KQNEENILNC FDKAIHGSLP IKMRITFSQR KVEFLEDFGS DVNKLLNAYD EHQTLLKEQD
TLKRKAENGS EEPEEKKAHT EDLSSAQIID GDLQANQAAY NYSAWYQYNY QNPWNYGQYY
PPPPT
