ID   PRP2_MOUSE              Reviewed;         317 AA.
AC   P05143; Q62103; Q62106;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Proline-rich protein 2;
DE   AltName: Full=Proline-rich protein MP-3;
DE   Flags: Precursor;
GN   Name=Prp2; Synonyms=Prh1, Prp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RC   STRAIN=CD-1; TISSUE=Liver;
RX   PubMed=2839509; DOI=10.1016/s0021-9258(18)38053-0;
RA   Ann D.K., Smith M.K., Carlson D.M.;
RT   "Molecular evolution of the mouse proline-rich protein multigene family.
RT   Insertion of a long interspersed repeated DNA element.";
RL   J. Biol. Chem. 263:10887-10893(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-317 (ISOFORM 1).
RX   PubMed=2999141; DOI=10.1016/s0021-9258(17)36338-x;
RA   Ann D.K., Carlson D.M.;
RT   "The structure and organization of a proline-rich protein gene of a mouse
RT   multigene family.";
RL   J. Biol. Chem. 260:15863-15872(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 116-317 (ISOFORM 2).
RX   PubMed=3840480; DOI=10.1016/s0021-9258(17)38745-8;
RA   Clements S., Mehansho H., Carlson D.M.;
RT   "Novel multigene families encoding highly repetitive peptide sequences.
RT   Sequence analyses of rat and mouse proline-rich protein cDNAs.";
RL   J. Biol. Chem. 260:13471-13477(1985).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P05143-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P05143-2; Sequence=VSP_026929;
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DR   EMBL; M23236; AAA53048.1; -; Genomic_DNA.
DR   EMBL; M12100; AAA40005.1; -; Genomic_DNA.
DR   EMBL; M19419; AAA40002.1; -; mRNA.
DR   PIR; A28996; A28996.
DR   PIR; D29149; D29149.
DR   AlphaFoldDB; P05143; -.
DR   STRING; 10090.ENSMUSP00000075435; -.
DR   GlyGen; P05143; 1 site.
DR   PaxDb; P05143; -.
DR   PRIDE; P05143; -.
DR   MGI; MGI:1932491; Prp2.
DR   PRO; PR:P05143; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P05143; protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026086; Pro-rich.
DR   PANTHER; PTHR23203; PTHR23203; 3.
DR   SMART; SM01412; Pro-rich; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..317
FT                   /note="Proline-rich protein 2"
FT                   /id="PRO_0000058467"
FT   REGION          15..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..317
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         176..189
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:3840480"
FT                   /id="VSP_026929"
FT   CONFLICT        122
FT                   /note="P -> Q (in Ref. 3; AAA40002)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        130
FT                   /note="P -> Q (in Ref. 2; AAA40005)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        159
FT                   /note="R -> K (in Ref. 3; AAA40002)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202
FT                   /note="Y -> S (in Ref. 3; AAA40002)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        224
FT                   /note="G -> A (in Ref. 3; AAA40002)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        310
FT                   /note="Q -> P (in Ref. 2; AAA40005)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   317 AA;  31719 MW;  019301BE31D73278 CRC64;
     MLVVLFTVAL LALSSAQGPR EELQNQIQIP NQRPPPSGSQ PRPPVNGSQQ GPPPPGGPQP
     RPPQGPPPPG GPQPRPPQGP PPPGGPQPRP PQGPPPPGGP QPRPPQGPPP PGGPQPRPPQ
     GPPPPGGPQP RPPQGPPPPG GPQQRPPQGP PPPGGPQPRP PQGPPPPAGP QPRPPQGPPP
     PAGPHLRPTQ GPPPTGGPQQ RYPQSPPPPG GPQPRPPQGP PPPGGPHPRP TQGPPPTGPQ
     PRPTQGPPPT GGPQQRPPQG PPPPGGPQPR PPQGPPPPTG PQPRPTQGPH PTGGPQQTPP
     LAGNPQGPPQ GRPQGPQ