PROY_SALTY
ID PROY_SALTY Reviewed; 456 AA.
AC P37460;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Proline-specific permease ProY;
GN Name=proY; OrderedLocusNames=STM0400;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=9308174; DOI=10.1099/00221287-143-9-2903;
RA Liao M.K., Gort S., Maloy S.;
RT "A cryptic proline permease in Salmonella typhimurium.";
RL Microbiology 143:2903-2911(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Permease that is involved in the transport across the
CC cytoplasmic membrane of proline.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC {ECO:0000305}.
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DR EMBL; X74420; CAA52441.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL19354.1; -; Genomic_DNA.
DR PIR; S35983; S35983.
DR RefSeq; NP_459395.1; NC_003197.2.
DR RefSeq; WP_001555879.1; NC_003197.2.
DR AlphaFoldDB; P37460; -.
DR SMR; P37460; -.
DR STRING; 99287.STM0400; -.
DR TCDB; 2.A.3.1.6; the amino acid-polyamine-organocation (apc) family.
DR PaxDb; P37460; -.
DR PRIDE; P37460; -.
DR EnsemblBacteria; AAL19354; AAL19354; STM0400.
DR GeneID; 1251919; -.
DR KEGG; stm:STM0400; -.
DR PATRIC; fig|99287.12.peg.427; -.
DR HOGENOM; CLU_007946_9_3_6; -.
DR OMA; PHWVWVL; -.
DR PhylomeDB; P37460; -.
DR BioCyc; SENT99287:STM0400-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR Pfam; PF00324; AA_permease; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..456
FT /note="Proline-specific permease ProY"
FT /id="PRO_0000054210"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..95
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..197
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..277
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..355
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..399
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421..424
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 446..456
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 456 AA; 50048 MW; EED5485A676F7783 CRC64;
MESNNKLKRG LSTRHIRFMA LGSAIGTGLF YGSADAIKMA GPSVLLAYII GGVAAYIIMR
ALGEMSVHNP AASSFSRYAQ ENLGPLAGYI TGWTYCFEIL IVAIADVTAF GIYMGVWFPA
VPHWIWVLSV VLIICAINLM SVKVFGELEF WFSFFKVATI IIMIVAGIGI IVWGIGNGGQ
PTGIHNLWSN GGFFSNGWLG MIMSLQMVMF AYGGIEIIGI TAGEAKDPEK SIPRAINSVP
MRILVFYVGT LFVIMSIYPW NQVGTNGSPF VLTFQHMGIT FAASILNFVV LTASLSAINS
DVFGVGRMLH GMAEQGSAPK VFAKTSRRGI PWVTVLVMTI ALLFAVYLNY IMPENVFLVI
ASLATFATVW VWIMILLSQI AFRRRLPPEE VKALKFKVPG GVVTTIAGLI FLVFIIALIG
YHPDTRISLY VGFAWIVLLL IGWIFKRRRD RQLAQA
