ID   PROTO_PROSY             Reviewed;          12 AA.
AC   P0C1R1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   02-JUN-2021, entry version 21.
DE   RecName: Full=Protonectin;
OS   Protonectarina sylveirae (Brazilian wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Epiponini; Protonectarina.
OX   NCBI_TaxID=91438;
RN   [1]
RP   PROTEIN SEQUENCE, SYNTHESIS, IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   AMIDATION AT LEU-12.
RC   TISSUE=Venom;
RX   PubMed=7513243; DOI=10.1002/nt.2620010503;
RA   Dohtsu K., Okumura K., Hagiwara K., Palma M.S., Nakajima T.;
RT   "Isolation and sequence analysis of peptides from the venom of
RT   Protonectarina sylveirae (Hymenoptera-Vespidae).";
RL   Nat. Toxins 1:271-276(1993).
CC   -!- FUNCTION: Shows potent antimicrobial action against both Gram-positive
CC       and Gram-negative bacteria (By similarity). This peptide shows potent
CC       histamine releasing activities on rat peritoneal mast cells.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Venom gland.
CC   -!- SIMILARITY: Belongs to the MCD family. Protonectin subfamily.
CC       {ECO:0000305}.
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DR   SMR; P0C1R1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Secreted.
FT   PEPTIDE         1..12
FT                   /note="Protonectin"
FT                   /id="PRO_0000247270"
FT   MOD_RES         12
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:7513243"
SQ   SEQUENCE   12 AA;  1211 MW;  0A7BB6110A287720 CRC64;
     ILGTILGLLK GL