PROS_DROVI
ID PROS_DROVI Reviewed; 1556 AA.
AC Q9U6A1;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Homeobox protein prospero;
GN Name=pros;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11051550; DOI=10.1016/s0092-8674(00)00107-0;
RA Xu C., Kauffmann R.C., Zhang J., Kladny S., Carthew R.W.;
RT "Overlapping activators and repressors delimit transcriptional response to
RT receptor tyrosine kinase signals in the Drosophila eye.";
RL Cell 103:87-97(2000).
CC -!- FUNCTION: Required for proper neuronal differentiation of most or all
CC neurons and their precursors in central and peripheral nervous systems,
CC axonal outgrowth and pathfinding. Not required for the specification of
CC neuronal identity. May regulate transcription by binding to DNA (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The Prospero-type homeodomain and the adjacent Prospero domain
CC act as a single structural unit, the Homeo-Prospero domain.
CC {ECO:0000255|PROSITE-ProRule:PRU01162}.
CC -!- SIMILARITY: Belongs to the Prospero homeodomain family.
CC {ECO:0000255|PROSITE-ProRule:PRU01162}.
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DR EMBL; AF190405; AAF06660.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9U6A1; -.
DR SMR; Q9U6A1; -.
DR eggNOG; KOG3779; Eukaryota.
DR ChiTaRS; pros; fly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.500; -; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR PANTHER; PTHR12198; PTHR12198; 2.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1..1556
FT /note="Homeobox protein prospero"
FT /id="PRO_0000208885"
FT DOMAIN 1398..1456
FT /note="Prospero-type homeo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT DOMAIN 1457..1556
FT /note="Prospero"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT REGION 150..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1556
FT /note="Homeo-Prospero"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01162"
FT MOTIF 1090..1097
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 224..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..475
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..644
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1556 AA; 171030 MW; 6FEACFEA2D73E644 CRC64;
MSSAAAAAAG AAGGALYTNN NITNNNNNNS NNNNSNITSS SNLSPTAATI ATTAAATTAT
ALSGSISPGS RESASSLLSA AFGNLFGGSS GENVKRAVRA TNEAGPGCHQ WAAQSLDNAM
LAAAMETATS ADLLNAAGLV SSLNTSKLLN NVNNNNNNNT PLSNGNNNNN NNASISPGSA
HSSTTKGGSS RRVSNCSDRS LDGNLAAAAT TAATDAAGGS PPRAASVSSL NGGASTQTKQ
QQLQHDLMAH HMLRNILQGK KELMQLDQEL RTAMQQQQQQ QQQQQNHEKH QQELHSKLNN
NTTTNNNNNV VSESINLIED SEMPEIKIKS EPELMASATQ APHSPHGGSS NSSSSHSHNS
SNNSIASNGS LRRKSSDSLD SMQREERATP ATTVEPQLQN EVLPTKKEAV DDMLDEVELL
GLSGHGHSRN SDLESLASPS HSDMLLLDNS KDEVLDNDDI IEDDEDDDDD DDDCIETKRE
SNTSGSNCLK KPGMELKRAR VEHIVSSMRC SPSATAQAGQ LQVNGCKKRK LYQPQQHAME
RYVAAAAGLN FGLNLQSMML DQEDSESNEL ESPQIQQKRV EKNALKSQLR SMQEQLAEMQ
QKYVQLCSRM EQESECQELD NEHEQDMDSM EQEQEQELEQ EQEQEPEPLQ QHNDDIELSH
SPTLSKSTPK ESSERAGSSS PYIEATEQQQ LLRAAATMLL PPRPICSLQM MSKMMSSKLQ
HQHNPLVGVA HPALPQGFPP LLQHMGDMSH AAAMYQQFFF EQEARMAKEA AEQQQQQQQQ
QQQQQQQQQQ QQQQQEQQRR YEQEQEQQRR MEEQQQQLHR QQQHLQQLQQ QQQQMEHHVA
AAVPRVQLHP PARLPTRMGG AAAAAAAAAH SVLKSELSEK FQMLRQHNSS SNSNNSSSNN
NNSNNNSSMM RMSGTDLEGL ADVLKSEITT SLSALVDTIV TRFVHQRRLF SKQADSVTAA
AEQLNKDLML ASQILDRKSP RTKVVADRGL SGNSGHPGAQ NGPTPATQSA AAMFQAPKTP
QGMNPVAAAA LYNSMASPFC LPPDQQQQQQ QQQQAAQQQQ QQAVQQQHQS AQQTQQQLEQ
NEALSLVVTP KKKRHKVTDT RITPRTVSRI LASGWRCAAQ WTGSCRSSCC RTTTTTTTTA
AAAAATTTAA ATEQQWQQQQ QQQCNAGTEP NGSRPGRRHI LSTATTTTTH DAGVFAHLSG
HTKSIAARIQ SLFAVQSILQ SACGAGPHGP PHGGQPTAAQ LHHQHHHQMQ LSSSPPGSLG
ALMDSRDSPP LPHPPTMLHP ALLAAAHHGG SPDYKTCLRA VMDAQDRQSE CNSADMTFDG
MQPTISFLKQ QQQQQSQLSG AHSVPMVNLW SLAPTHTLGT NVETSWVETA LTIITIYHTI
YDIYTFSNHC ESLTPLHSST LTPMHLRKAK LMFFWVRYPS SAVLKMYFPD IKFNKNNTAQ
LVKWFSNFRE FYYIQMEKYA RQAVTEGIKT PDDLLIAGDS ELYRVLNLHY NRNNHIEVPQ
NFRFVVEQTL REFFRAIQGG KDTEQSWKKS IYKIISRMDD PVPEYFKSPN FLEQLE
