ID   PRGR_SHEEP              Reviewed;         377 AA.
AC   Q28590;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Progesterone receptor;
DE            Short=PR;
DE   AltName: Full=Nuclear receptor subfamily 3 group C member 3;
DE   Flags: Fragment;
GN   Name=PGR; Synonyms=NR3C3;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Romanov; TISSUE=Uterus;
RA   Madigou T., Tiffoche C., le Gal F., Pelletier J., Thieulant M.;
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC       regulation of eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues. Transcriptional
CC       activator of several progesteron-dependent promoters in a variety of
CC       cell types. Involved in activation of SRC-dependent MAPK signaling on
CC       hormone stimulation. {ECO:0000250|UniProtKB:P06401}.
CC   -!- SUBUNIT: Interacts with CUEDC2, SMARD1 and with UNC45A. Interacts with
CC       PRMT2. Interacts with NCOA2 and NCOA1. Interacts with KLF9. Interacts
CC       with GTF2B (By similarity). {ECO:0000250|UniProtKB:P06401,
CC       ECO:0000250|UniProtKB:Q00175}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- PTM: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required
CC       for plasma membrane targeting and for rapid intracellular signaling via
CC       ERK and AKT kinases and cAMP generation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; Z66555; CAA91447.1; -; mRNA.
DR   AlphaFoldDB; Q28590; -.
DR   SMR; Q28590; -.
DR   STRING; 9940.ENSOARP00000008411; -.
DR   ChEMBL; CHEMBL3271928; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Lipid-binding; Lipoprotein; Metal-binding; Nucleus; Palmitate;
KW   Phosphoprotein; Receptor; Reference proteome; Steroid-binding;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..>377
FT                   /note="Progesterone receptor"
FT                   /id="PRO_0000053698"
FT   DOMAIN          130..364
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        16..90
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         18..38
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         54..78
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          <1..15
FT                   /note="Modulating, Pro-Rich"
FT   REGION          138..>377
FT                   /note="AF2; mediates transcriptional activation"
FT                   /evidence="ECO:0000250|UniProtKB:P06401"
FT   MOD_RES         127
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P06401"
FT   NON_TER         1
FT   NON_TER         377
SQ   SEQUENCE   377 AA;  42904 MW;  3141B65587F7493C CRC64;
     EASQSPQYSF ESLPQKICLI CGDEASGCHY GVLTCGSCKV FFKRAMEGQH NYLCAGRNDC
     IVDKIRRKNC PACRLRKCCQ AGMVLGGRKF KKFNKVRVMR TLDAVALPQP VGIPNESQAL
     SQRITFSPSQ DLQLIPPLIN LLMSIEPDMV YAGHDNSKPD TSSSLLTSLN QLGERQLLSV
     VKWSKSLPGF RNLHIDDQIT LIQYSWMSLM VFGLGWRSYK HVSGQMLYFA PDLILNEQRM
     KESSFYSLCL TMWQIPQEFV KLQVSQEEFL CMKVLLLLNT IPLEGLRSQN QFEEMRSSYI
     RELIKAIGLR QKGVVPSSQR FYQLTKLLDN LHDLVKQLHL YCLNTFIQSR ALSVEFPEMM
     SEVIAAQLPK ILAGMVK