ID   PPR42_MACFA             Reviewed;         357 AA.
AC   Q4R803;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 42;
DE   AltName: Full=Leucine-rich repeat-containing protein 67;
GN   Name=PPP1R42; Synonyms=LRRC67; ORFNames=QtsA-13888;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates phosphatase activity of protein phosphatase 1 (PP1)
CC       complexes in the testis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PPP1CC isoform gamma-2; the interaction is
CC       direct. Interacts with actin, dynein, KIF5B, KIFC1 and tubulin.
CC       Associates with microtubules (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Note=Colocalizes with alpha tubulin to the manchette of developing
CC       spermatids. Detected to nuclear rim in pachytene spermatocytes.
CC       Detected at nuclear surface, opposite the acrosome in elongating
CC       spermatids. Detected at the microtubule-organizing center (MTOC).
CC       Localized to the centrosomal region of late-stage spermatids (By
CC       similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated; in the testis. {ECO:0000250}.
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DR   EMBL; AB168658; BAE00769.1; -; mRNA.
DR   RefSeq; NP_001306489.1; NM_001319560.1.
DR   AlphaFoldDB; Q4R803; -.
DR   SMR; Q4R803; -.
DR   STRING; 9541.XP_005563513.1; -.
DR   GeneID; 102143059; -.
DR   CTD; 286187; -.
DR   eggNOG; KOG2769; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0002177; C:manchette; ISS:UniProtKB.
DR   GO; GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0005815; C:microtubule organizing center; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; ISS:UniProtKB.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF12799; LRR_4; 1.
DR   PROSITE; PS51450; LRR; 6.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..357
FT                   /note="Protein phosphatase 1 regulatory subunit 42"
FT                   /id="PRO_0000326176"
FT   REPEAT          29..50
FT                   /note="LRR 1"
FT   REPEAT          51..72
FT                   /note="LRR 2"
FT   REPEAT          73..94
FT                   /note="LRR 3"
FT   REPEAT          95..116
FT                   /note="LRR 4"
FT   REPEAT          117..138
FT                   /note="LRR 5"
FT   REPEAT          147..168
FT                   /note="LRR 6"
FT   REPEAT          169..190
FT                   /note="LRR 7"
FT   DOMAIN          204..242
FT                   /note="LRRCT"
SQ   SEQUENCE   357 AA;  41223 MW;  CE9496D2AC07A5E0 CRC64;
     MVRLTLDLIA RNSNLKPRKE ETISQCLKKI THINFSDKNI DAIEDLSLCK NLSVLYLYDN
     CISQITNLNY ATNLTHLYLQ NNCIPCIENL RSLKKLEKLY LGGNYIAVIE GLEGLGELRE
     LHVENQRLPL GEKLLFDPRT LHSLAKSLSI LNISNNNIDD IRDLEILENL NQLIAVDNQL
     LHVKDLEFLL NKLMKLWKID LNGNPVCLKP KYRDRLILVS KSLEFLDGKE IKNIERQFLM
     NWKASKDAKK ISKKRSSKNE DASNSLISNF ETMHHIVPVY YPQVGKPKLV FFSEIQRYPV
     NGNASPESSR EDYTKIIEEM GNLSLKQSES LLTKNDVHEP HLFHNPKEKE NLFAENE