ID   PPR3B_DANRE             Reviewed;         293 AA.
AC   Q803M0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 3B;
GN   Name=ppp1r3b; ORFNames=zgc:55542;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a glycogen-targeting subunit for phosphatase PP1.
CC       Facilitates interaction of the PP1 with enzymes of the glycogen
CC       metabolism and regulates its activity. Suppresses the rate at which PP1
CC       dephosphorylates (inactivates) glycogen phosphorylase and enhances the
CC       rate at which it activates glycogen synthase and therefore limits
CC       glycogen breakdown (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and
CC       PYGL. Associates with glycogen particles. Forms complexes with
CC       debranching enzyme, glycogen phosphorylase, glycogen synthase and
CC       phosphorylase kinase which is necessary for its regulation of PP1
CC       activity (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal region is required for binding to PP1, the
CC       central region is required for binding to glycogen and the C-terminal
CC       region is required for binding to glycogen phosphorylase, glycogen
CC       synthase and phosphorylase kinase. {ECO:0000250}.
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DR   EMBL; BC044421; AAH44421.1; -; mRNA.
DR   EMBL; BC154237; AAI54238.1; -; mRNA.
DR   RefSeq; NP_997874.1; NM_212709.1.
DR   AlphaFoldDB; Q803M0; -.
DR   SMR; Q803M0; -.
DR   STRING; 7955.ENSDARP00000065669; -.
DR   CAZy; CBM21; Carbohydrate-Binding Module Family 21.
DR   PaxDb; Q803M0; -.
DR   PRIDE; Q803M0; -.
DR   Ensembl; ENSDART00000065670; ENSDARP00000065669; ENSDARG00000044691.
DR   Ensembl; ENSDART00000180816; ENSDARP00000145267; ENSDARG00000044691.
DR   Ensembl; ENSDART00000186251; ENSDARP00000153052; ENSDARG00000110639.
DR   Ensembl; ENSDART00000186479; ENSDARP00000149271; ENSDARG00000114900.
DR   GeneID; 327285; -.
DR   KEGG; dre:327285; -.
DR   CTD; 79660; -.
DR   ZFIN; ZDB-GENE-030131-5496; ppp1r3b.
DR   eggNOG; KOG3986; Eukaryota.
DR   GeneTree; ENSGT00940000159475; -.
DR   HOGENOM; CLU_040215_2_1_1; -.
DR   InParanoid; Q803M0; -.
DR   OMA; GIAFDQF; -.
DR   OrthoDB; 1232750at2759; -.
DR   PhylomeDB; Q803M0; -.
DR   TreeFam; TF105537; -.
DR   PRO; PR:Q803M0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000044691; Expressed in cleaving embryo and 28 other tissues.
DR   ExpressionAtlas; Q803M0; baseline and differential.
DR   GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR   GO; GO:2001069; F:glycogen binding; IBA:GO_Central.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro.
DR   GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0005979; P:regulation of glycogen biosynthetic process; IBA:GO_Central.
DR   GO; GO:0005981; P:regulation of glycogen catabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.2440; -; 1.
DR   InterPro; IPR005036; CBM21_dom.
DR   InterPro; IPR038175; CBM21_dom_sf.
DR   InterPro; IPR017434; Pase-1_reg-su_3B/C/D_met.
DR   InterPro; IPR030682; PP1_3B.
DR   PANTHER; PTHR12307:SF13; PTHR12307:SF13; 1.
DR   Pfam; PF03370; CBM_21; 1.
DR   PIRSF; PIRSF500814; PP1_GL; 1.
DR   PIRSF; PIRSF038207; PP1_GT_animal; 1.
DR   PROSITE; PS51159; CBM21; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Glycogen metabolism; Reference proteome.
FT   CHAIN           1..293
FT                   /note="Protein phosphatase 1 regulatory subunit 3B"
FT                   /id="PRO_0000324546"
FT   DOMAIN          129..237
FT                   /note="CBM21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
SQ   SEQUENCE   293 AA;  33712 MW;  F7E51A72311B8D81 CRC64;
     MPIELAMSLY LSSDEFLNPR ASKYSRPLQP CLNQCKSSKL SFSSLKEQSE FNGVSRALMI
     PGRAKKHVSF ADHKGLALTV VKIFSEFDDP IDIPDNIDNF FTSSLTVSEG KDKLTLDFDQ
     PSADYLKFRQ RIENDHVCLE HCMLKEKSIM GTVKVKNISF EKSVKLRITF NTWKNHTDVE
     CQYVKDTYTG SNRDTFSFEA SLPEQVPSHE RIEFAICYEV NGDTLWDNNQ GKNYRIIQSA
     LRKSSNESNG GHQQYSQSDW DIHFDRYGSP RCSRGIFPHW PSYVGYEDIG PYY