PPR37_MOUSE
ID PPR37_MOUSE Reviewed; 712 AA.
AC Q8BKR5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 37;
DE AltName: Full=Leucine-rich repeat-containing protein 68;
GN Name=Ppp1r37; Synonyms=Lrrc68;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC complexes. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PPP1CA. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PPP1R37 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK050946; BAC34471.1; -; mRNA.
DR EMBL; BC070402; AAH70402.1; -; mRNA.
DR CCDS; CCDS20906.1; -.
DR RefSeq; NP_954600.1; NM_199149.3.
DR AlphaFoldDB; Q8BKR5; -.
DR SMR; Q8BKR5; -.
DR BioGRID; 231330; 1.
DR IntAct; Q8BKR5; 1.
DR STRING; 10090.ENSMUSP00000060233; -.
DR iPTMnet; Q8BKR5; -.
DR PhosphoSitePlus; Q8BKR5; -.
DR EPD; Q8BKR5; -.
DR jPOST; Q8BKR5; -.
DR MaxQB; Q8BKR5; -.
DR PaxDb; Q8BKR5; -.
DR PeptideAtlas; Q8BKR5; -.
DR PRIDE; Q8BKR5; -.
DR ProteomicsDB; 289878; -.
DR Antibodypedia; 49146; 50 antibodies from 12 providers.
DR DNASU; 232947; -.
DR Ensembl; ENSMUST00000058444; ENSMUSP00000060233; ENSMUSG00000051403.
DR GeneID; 232947; -.
DR KEGG; mmu:232947; -.
DR UCSC; uc009fmh.1; mouse.
DR CTD; 284352; -.
DR MGI; MGI:2687042; Ppp1r37.
DR VEuPathDB; HostDB:ENSMUSG00000051403; -.
DR eggNOG; KOG1908; Eukaryota.
DR GeneTree; ENSGT00940000157454; -.
DR HOGENOM; CLU_014302_0_0_1; -.
DR InParanoid; Q8BKR5; -.
DR OMA; EHELRCP; -.
DR OrthoDB; 1186874at2759; -.
DR PhylomeDB; Q8BKR5; -.
DR TreeFam; TF328391; -.
DR BioGRID-ORCS; 232947; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ppp1r37; mouse.
DR PRO; PR:Q8BKR5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BKR5; protein.
DR Bgee; ENSMUSG00000051403; Expressed in humerus cartilage element and 245 other tissues.
DR Genevisible; Q8BKR5; MM.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 3.
DR PROSITE; PS51450; LRR; 5.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Phosphoprotein; Protein phosphatase inhibitor;
KW Reference proteome; Repeat.
FT CHAIN 1..712
FT /note="Protein phosphatase 1 regulatory subunit 37"
FT /id="PRO_0000320940"
FT REPEAT 226..246
FT /note="LRR 1"
FT REPEAT 254..275
FT /note="LRR 2"
FT REPEAT 283..303
FT /note="LRR 3"
FT REPEAT 312..332
FT /note="LRR 4"
FT REPEAT 340..360
FT /note="LRR 5"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..533
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..629
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75864"
FT MOD_RES 62
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B2RYF1"
FT MOD_RES 583
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75864"
SQ SEQUENCE 712 AA; 77574 MW; 046EE80CE36D3159 CRC64;
MEIPPQEAPP GPGADADADA EAETEEASAE AESPTGTSPP ADGRLKAAAK RVTFPSDEDI
VSGAVEPKDP WRHAQNVTVD EVISAYRQAC QKLNCRQIPK LLRQLQEFTD LEQRINCLDL
KGEKLDYKTC EALEEVFKRL QFKVVDLEQT NLDEDGASAL FDMIEYYESA THLNISFNKH
IGTRGWQAAA HMMRKTSCLQ YLDARNTPLL DHSAPFVARA LRIRSSLAVL HLENASLSGR
PLMLLATALK MNMNLRELYL ADNKLNGLQD SAQLGNLLKF NCSLQILDLR NNHVLDSGLA
YICEGLKEQR KGLVTLVLWN NQLTHTGMAF LGMALPHTQS LETLNLGHNP IGNEGVRNLK
NGLISNRSVL RLGLASTKLT CEGAVAVAEF IAESPRLLRL DLRENEIKTG GLMALSLALK
VNHSLLRLDL DREPKKEPVK SFIETQKALL AEIQNGCKRN FVLVREREEK QQLQLSASMP
EITITAPQPL EESGELPAVG SQNGAPRPGP GPDSDSDSDS DREEQEEEEE DQRNQQRDEG
GNDQSSLASC PALIPSTDSL GPGDKSPPSS PSSPTEQRIS VSSPGRGHKV FVVTRVESPP
ERPEPPVPPT FVSSPPPSPP SPPASPPSQT MDTQDPESSE AQPQLEPSQA GQPLPNGLKP
EFALALPPEP PPGLEAKGGS CSLEHALHRS QGVSKLEELL LEASQEAPRD TL
