PPR37_DANRE
ID PPR37_DANRE Reviewed; 919 AA.
AC Q1L994; A7YXZ6; Q08C55;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 37;
DE AltName: Full=Leucine-rich repeat-containing protein 68;
GN Name=ppp1r37; Synonyms=lrrc68; ORFNames=si:ch211-234g24.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May inhibit phosphatase activity of protein phosphatase 1
CC (PP1) complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PPP1R37 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI24388.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI24388.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; CR381630; CAK04639.1; -; Genomic_DNA.
DR EMBL; BC124387; AAI24388.1; ALT_SEQ; mRNA.
DR EMBL; BC141792; AAI41793.1; -; mRNA.
DR AlphaFoldDB; Q1L994; -.
DR SMR; Q1L994; -.
DR PaxDb; Q1L994; -.
DR ZFIN; ZDB-GENE-050208-7; ppp1r37.
DR eggNOG; KOG1908; Eukaryota.
DR InParanoid; Q1L994; -.
DR PhylomeDB; Q1L994; -.
DR TreeFam; TF328391; -.
DR PRO; PR:Q1L994; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 2.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Coiled coil; Leucine-rich repeat; Protein phosphatase inhibitor;
KW Reference proteome; Repeat.
FT CHAIN 1..919
FT /note="Protein phosphatase 1 regulatory subunit 37"
FT /id="PRO_0000320941"
FT REPEAT 340..361
FT /note="LRR 1"
FT REPEAT 368..388
FT /note="LRR 2"
FT REPEAT 396..417
FT /note="LRR 3"
FT REPEAT 425..445
FT /note="LRR 4"
FT REPEAT 454..474
FT /note="LRR 5"
FT REPEAT 482..502
FT /note="LRR 6"
FT REGION 626..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 833..861
FT /evidence="ECO:0000255"
FT COMPBIAS 637..656
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 19
FT /note="V -> A (in Ref. 2; AAI41793)"
FT /evidence="ECO:0000305"
FT CONFLICT 98..99
FT /note="LA -> PV (in Ref. 2; AAI41793)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="E -> G (in Ref. 2; AAI24388)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="L -> S (in Ref. 2; AAI41793)"
FT /evidence="ECO:0000305"
FT CONFLICT 609
FT /note="K -> R (in Ref. 2; AAI41793)"
FT /evidence="ECO:0000305"
FT CONFLICT 632
FT /note="H -> HE (in Ref. 2; AAI41793)"
FT /evidence="ECO:0000305"
FT CONFLICT 776
FT /note="M -> L (in Ref. 2; AAI41793)"
FT /evidence="ECO:0000305"
FT CONFLICT 842..888
FT /note="Missing (in Ref. 2; AAI41793)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 919 AA; 100325 MW; A9D8D98CF8AAB0F4 CRC64;
MNCEDQAVDL CKAIDLCNVS DNTISHPTPA EEILPRDGLQ LMDGDQEEQD AAVLTRLKDV
HLKDDALHTK NNGSIAVSAD PVNGSAGDLQ QSTVEEPLAT KCSVGDVGDD GEMDIGVDLS
LDENGVLEFE PTAQTQSEES ASSCENSLIS DTVIELHSQE PLEEHSVDVP SETVPAAATP
VVEEAGIKHG LKRVTFPSDE DIVSGAVEPK DPWRHAQNVT VEEILNAYRQ ACQKLNCKPI
PKVLKQTQDL KDLTQRNECL DLKGEKLDYK SCESLEEIFK RVQFKLVDLE QTNLDEDGAS
ALFDMIEYYE SATHLNISNN KHIGTRGWQA AAHMMRKTNS LQYLDARNTP LLDHSAPFVA
RALRISSSLT VLHLENSGIS GRPLMLLATA LKMNMNLREL YLAENKLNGL QDSAQLGNLL
KFNYNIQILD LRNNHILDSG LAYVCEGLKE QRKGLVTLVL WNNQLTHNGM GYLAAALPFT
QSLETLNLGH NAVGNEGVHK LKDGLISNRS ILRLGLASTK LSCEGAVAIA EFIAESPRLL
RLDMRENEIK TGGLMALSLA FKVNTSLLRL DLDREPKKET VKSFIETQRA LLADIQNGCK
RNFILAREKE ETEQKMRLSA SMAEIATEDQ THEEEEEEEA SPLKKIEEET TDALKDATQE
SSEVSENQEP KDQESTPQDD SDSDTEDEET PTNTSLTSTS PIPIPAAADT SKTIPSTPPI
ASPAVISGIT VTEASIVTPS SPGRCISVSS PGRGHKIFMV TRVESPPEQQ QTSIAMLKSI
QPSAITDIKA PSQTQNSTQP TEKSHAEKTP DAQQEDSVST STPSLDANID QTQLTESVSE
EEQKKAETLN NEADINEDAN TGAPLPNGLK PEFALFEFEG AKPASCIMEH VSVTAELSCG
QDLEELLLDA SLETSRDAP
