ID   PPR37_CAEEL             Reviewed;         944 AA.
AC   Q19857; Q23160; Q8I0R8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 5.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 37 homolog;
GN   ORFNames=F28C1.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q19857-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q19857-2; Sequence=VSP_031756;
CC   -!- SIMILARITY: Belongs to the PPP1R37 family. {ECO:0000305}.
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DR   EMBL; Z75539; CAD54134.1; -; Genomic_DNA.
DR   EMBL; Z75552; CAD54134.1; JOINED; Genomic_DNA.
DR   EMBL; Z75539; CAA99846.3; -; Genomic_DNA.
DR   EMBL; Z75552; CAA99846.3; JOINED; Genomic_DNA.
DR   PIR; C89243; C89243.
DR   PIR; T21471; T21471.
DR   RefSeq; NP_506126.2; NM_073725.4. [Q19857-1]
DR   RefSeq; NP_872197.1; NM_182397.3. [Q19857-2]
DR   AlphaFoldDB; Q19857; -.
DR   SMR; Q19857; -.
DR   PaxDb; Q19857; -.
DR   PRIDE; Q19857; -.
DR   EnsemblMetazoa; F28C1.3a.1; F28C1.3a.1; WBGene00009201. [Q19857-1]
DR   EnsemblMetazoa; F28C1.3b.1; F28C1.3b.1; WBGene00009201. [Q19857-2]
DR   GeneID; 179708; -.
DR   KEGG; cel:CELE_F28C1.3; -.
DR   UCSC; F28C1.3a; c. elegans. [Q19857-1]
DR   CTD; 179708; -.
DR   WormBase; F28C1.3a; CE31919; WBGene00009201; -. [Q19857-1]
DR   WormBase; F28C1.3b; CE31920; WBGene00009201; -. [Q19857-2]
DR   eggNOG; KOG1908; Eukaryota.
DR   GeneTree; ENSGT00940000157454; -.
DR   HOGENOM; CLU_311279_0_0_1; -.
DR   InParanoid; Q19857; -.
DR   OMA; IEFYDSC; -.
DR   OrthoDB; 294047at2759; -.
DR   PhylomeDB; Q19857; -.
DR   PRO; PR:Q19857; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00009201; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q19857; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 2.
PE   3: Inferred from homology;
KW   Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..944
FT                   /note="Protein phosphatase 1 regulatory subunit 37 homolog"
FT                   /id="PRO_0000320943"
FT   REPEAT          203..224
FT                   /note="LRR 1"
FT   REPEAT          232..255
FT                   /note="LRR 2"
FT   REPEAT          262..282
FT                   /note="LRR 3"
FT   REPEAT          290..311
FT                   /note="LRR 4"
FT   REPEAT          318..338
FT                   /note="LRR 5"
FT   REGION          42..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..544
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         481..485
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_031756"
SQ   SEQUENCE   944 AA;  104236 MW;  3E29F9E54A3E4FF6 CRC64;
     MSMKFLTGLQ DLLGLYETGT AASSPASPIP PTSPAMFAVP PQQQSHSAAT SVRKKTCQDA
     NSSGEDPNGR IRQCSHARTV SFPADMDLIT GYHEAPSSLF HSYHDSQRVI DSSEILTAYR
     EACQRRQCAP SAAVEKQIGY FHKSPDTRQE LLSLKGERVS HAQMEALEEI FKRVQFNTID
     FEYTFLDDDC AISLGEMIEF YDSCVRLNLS FNKQIDMRGW TTIFRSIRHA VSLQMLNLRY
     TNLNDRSIPA LCKMARAQPS ASLTCLHLEN TQMSGKNLLV LICALKNNTG LRELYLGDNG
     LQPTDGSHIY QLITSNSSLQ LLDLRNNSIG DSGVRHICDG LRHREAVEKS SLSAMVLWNN
     NVTGASMDSL AEALIENTKI ETLNIGNNNL GVEGIARLKP ALASNSHLHR LGLQNTGINC
     EGAIILAECI ADNIALLRVD IRDNPIALAG LLALHSAMKM NTSITLLNID ASCVKLSSEK
     VREYQDEFER YFREIQTYCD RNKDDVLKRL TVTFDDEEGD SGVEKKDGNE CEGEDNKDRQ
     DTPAETENGV SSNESKLENE EVGVSKPESN NNEKSPLMAS SSTSKLSRKE RHQRFVRSSS
     LTCTETVHDI HDRLREMSGS THSLDAAIAA AASNSTMQNL LTVSYGSNPG PLDSSSNSES
     MKTIKKSFTV TAASSSSLPL AEWGSLPALP QASPSSTPVV RKLRRFSVSP SSSVFDVATT
     SSAASSTASS PIPENSIALP VRPSTLAIGI PIIGSVPAGP SSAPLILVED HKDGPITSNQ
     ISDTERRISE EIERQKKDEQ EIEKSCRSVI RDLLNYVEYE EKSQVERKAS LLLRNTFSRP
     NPEELLRNLR LSEATGSTTP RTPLTPSRYV QVFNINSFLK LYFIKACILR VLEIAEELEG
     ESDEQICQSV IRCLVRDVLQ AEKNELRSTL DRRRRHNSVR NSPV