ID   PPR37_BOVIN             Reviewed;         699 AA.
AC   A7Z026;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 37;
DE   AltName: Full=Leucine-rich repeat-containing protein 68;
GN   Name=PPP1R37; Synonyms=LRRC68;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1)
CC       complexes. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PPP1CA. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PPP1R37 family. {ECO:0000305}.
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DR   EMBL; BC153224; AAI53225.1; -; mRNA.
DR   RefSeq; NP_001098849.1; NM_001105379.1.
DR   AlphaFoldDB; A7Z026; -.
DR   SMR; A7Z026; -.
DR   STRING; 9913.ENSBTAP00000025071; -.
DR   PaxDb; A7Z026; -.
DR   PRIDE; A7Z026; -.
DR   Ensembl; ENSBTAT00000025071; ENSBTAP00000025071; ENSBTAG00000018834.
DR   GeneID; 516932; -.
DR   KEGG; bta:516932; -.
DR   CTD; 284352; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018834; -.
DR   VGNC; VGNC:33241; PPP1R37.
DR   eggNOG; KOG1908; Eukaryota.
DR   GeneTree; ENSGT00940000157454; -.
DR   HOGENOM; CLU_014302_0_0_1; -.
DR   InParanoid; A7Z026; -.
DR   OMA; EHELRCP; -.
DR   OrthoDB; 1186874at2759; -.
DR   TreeFam; TF328391; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000018834; Expressed in diaphragm and 104 other tissues.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 3.
DR   PROSITE; PS51450; LRR; 5.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Phosphoprotein; Protein phosphatase inhibitor;
KW   Reference proteome; Repeat.
FT   CHAIN           1..699
FT                   /note="Protein phosphatase 1 regulatory subunit 37"
FT                   /id="PRO_0000320938"
FT   REPEAT          220..240
FT                   /note="LRR 1"
FT   REPEAT          248..269
FT                   /note="LRR 2"
FT   REPEAT          277..297
FT                   /note="LRR 3"
FT   REPEAT          306..326
FT                   /note="LRR 4"
FT   REPEAT          334..354
FT                   /note="LRR 5"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          467..667
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        584..642
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         50
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75864"
FT   MOD_RES         56
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:B2RYF1"
FT   MOD_RES         566
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75864"
SQ   SEQUENCE   699 AA;  75697 MW;  B3C19171B2DFF3C1 CRC64;
     MEIPPQEAPP GPGADGEAEE APVEAPSPGP ASPPADGRLK AAAKRVTFPS DEDIVSGAVE
     PKDPWRHAQN VTVDEIIGAY KQACQKLNCR QIPKLLRQLQ EFTDLGHRID CLDLKGEKLD
     YKTCEALEEV FKRLQFKVVD LEQTNLDEDG ASALFDMIEY YESATHLNIS FNKHIGTRGW
     QAAAHMMRKT SCLQYLDARN TPLLDHSAPF VARALRIRSS LAVLHLESSS LSGRPLMLLA
     TALKMNMTLR ELYLADNKLN GLQDSAQLGN LLKFNCSLQI LDLRNNHVLD SGLAYICEGL
     KEQRKGLATL VLWNNQLTHT GMAFLGMTLP HTHSLETLNL GHNPIGNEGV RNLKNGLISN
     RSVLRLGLAS TKLTCEGAVA VAEFIAESPR LLRLDLRENE IKTGGLMALS LALKVNHSLL
     RLDLDREPKK EAVKSFIETQ KALLAEIQNG CKRNFVLVRE REEKEQRLQL SASMPEITVT
     EPQPDDEPRE EPAAEAQENG APGPSPGPDS DSDSDSEGED RDEADGERAE APCPTLVPPT
     DSLGPGDRSP PGCPSSPAEQ RISVSSPGWG HKVFVVTRVE SPPERAEPPV PPAPPGPVSP
     PASASPPTSP FPTPTEAAST PDPGPPEPQP PLEPPQVGPP LPNGLKPEFA LALSPEPPPG
     PEAKVGSCGL EHELSCSKNE KELEELLLEA SQESGQETL