ID   POM33_CHATD             Reviewed;         287 AA.
AC   G0S6T0; G0ZGV8;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Nucleoporin POM33 {ECO:0000303|PubMed:21784248};
DE   AltName: Full=Nuclear pore protein POM33;
DE   AltName: Full=Pore membrane protein of 33 kDa;
GN   Name=POM33; ORFNames=CTHT_0035480;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Contributes to proper distribution and/or efficient assembly
CC       of nuclear pores. {ECO:0000250|UniProtKB:Q12164}.
CC   -!- SUBUNIT: The nuclear pore complex (NPC) constitutes the exclusive means
CC       of nucleocytoplasmic transport. NPCs allow the passive diffusion of
CC       ions and small molecules and the active, nuclear transport receptor-
CC       mediated bidirectional transport of macromolecules such as proteins,
CC       RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the
CC       nuclear envelope. The 55-60 MDa NPC is composed of at least 28
CC       different subunits: AMO1, ELYS, GLE1, GLE2, MLP1, NDC1, NIC96, NSP1,
CC       NUP133, NUP145, NUP152, NUP159, NUP170, NUP188, NUP192, NUP37, NUP49,
CC       NUP53, NUP56, NUP57, NUP82, NUP84, NUP85, POM152, POM33, POM34, SEC13
CC       and SEH1. Due to its 8-fold rotational symmetry, all subunits are
CC       present with 8 copies or multiples thereof.
CC       {ECO:0000250|UniProtKB:Q12164, ECO:0000305|PubMed:21784248}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q12164};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12164}. Nucleus,
CC       nuclear pore complex {ECO:0000250|UniProtKB:Q12164}.
CC   -!- SIMILARITY: Belongs to the PER33/POM33 family. {ECO:0000305}.
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DR   EMBL; GL988041; EGS21682.1; -; Genomic_DNA.
DR   EMBL; JF276303; AEL00696.1; -; Genomic_DNA.
DR   RefSeq; XP_006693978.1; XM_006693915.1.
DR   AlphaFoldDB; G0S6T0; -.
DR   STRING; 759272.G0S6T0; -.
DR   TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR   EnsemblFungi; EGS21682; EGS21682; CTHT_0035480.
DR   GeneID; 18257586; -.
DR   KEGG; cthr:CTHT_0035480; -.
DR   eggNOG; KOG4002; Eukaryota.
DR   HOGENOM; CLU_065417_2_0_1; -.
DR   OrthoDB; 1360050at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005344; TMEM33/Pom33.
DR   Pfam; PF03661; TMEM33_Pom33; 1.
PE   3: Inferred from homology;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..287
FT                   /note="Nucleoporin POM33"
FT                   /id="PRO_0000433196"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12164"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..53
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000250|UniProtKB:Q12164"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..103
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12164"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..183
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000250|UniProtKB:Q12164"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..287
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12164"
SQ   SEQUENCE   287 AA;  32671 MW;  9C546F6B9BA6BD8D CRC64;
     MAPPPPSADV PLAERLQRLA STLQFAWFSG HALLLLCVFR YAFSWIRFNY YSGMARFCYR
     FAFIAAAATY GIVVYKTWRA RQKTGVKTSG IKDYLRDENI QYLVLALVWL FMPQYPLALL
     PYGIYSVFHV ATYVRANLIP TLVPPQRINA PAGASPNAKP QYTQHPASEA IGVFVKKYYD
     SSMSMVARLE IMLWLRLILS VILFQRRSWI LFAIYTTFLR TRFSQSIHVQ NAFALLEARI
     DNLIGAQGTP PQARQVWDNV KTAARQFYAV TDLNKYESGV AAPKKSS