POGK_MOUSE
ID POGK_MOUSE Reviewed; 607 AA.
AC Q80TC5; Q8BPJ3; Q8C887;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Pogo transposable element with KRAB domain;
GN Name=Pogk; Synonyms=Kiaa1513;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC33234.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC35580.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC65802.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK048067; BAC33234.1; ALT_INIT; mRNA.
DR EMBL; AK053898; BAC35580.1; ALT_INIT; mRNA.
DR EMBL; AK122520; BAC65802.1; ALT_INIT; mRNA.
DR RefSeq; NP_001136420.1; NM_001142948.1.
DR RefSeq; NP_780379.2; NM_175170.4.
DR AlphaFoldDB; Q80TC5; -.
DR SMR; Q80TC5; -.
DR STRING; 10090.ENSMUSP00000127395; -.
DR PhosphoSitePlus; Q80TC5; -.
DR MaxQB; Q80TC5; -.
DR PaxDb; Q80TC5; -.
DR PRIDE; Q80TC5; -.
DR ProteomicsDB; 289717; -.
DR DNASU; 71592; -.
DR GeneID; 71592; -.
DR KEGG; mmu:71592; -.
DR UCSC; uc007dko.2; mouse.
DR CTD; 57645; -.
DR MGI; MGI:1918842; Pogk.
DR eggNOG; KOG3105; Eukaryota.
DR InParanoid; Q80TC5; -.
DR OrthoDB; 1343623at2759; -.
DR PhylomeDB; Q80TC5; -.
DR BioGRID-ORCS; 71592; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Pogk; mouse.
DR PRO; PR:Q80TC5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q80TC5; protein.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR003655; aKRAB.
DR InterPro; IPR018586; Brinker_DNA-bd.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR Pfam; PF09607; BrkDBD; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00674; CENPB; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50805; KRAB; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Developmental protein; DNA-binding; Isopeptide bond; Nucleus;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..607
FT /note="Pogo transposable element with KRAB domain"
FT /id="PRO_0000126132"
FT DOMAIN 47..118
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT DOMAIN 250..323
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 355..567
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT REGION 588..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..29
FT /evidence="ECO:0000255"
FT CROSSLNK 13
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9P215"
FT CROSSLNK 384
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9P215"
FT CONFLICT 177
FT /note="P -> H (in Ref. 1; BAC35580)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 607 AA; 69598 MW; C9BB589C223F3596 CRC64;
MESRAYPLNL TLKEEQKEEE VEIQELEDGP IDMQKVQICS EGAWVPALFD EVAIYFSDEE
WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMINRLE RDEECPNSDE WRLQGVTFAE
NEESDFRTPD WASPTNATSH FPQPQPFNSF GLRLPQDITE LPEWTEGYPF YMAMGFPGYD
LSADDLASKF QFSRGMRRSY DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ
LQNAHAMRRA FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE
KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LAEDLTEKLV TYQQSVLALR RTHDYEVAQM
GNADETPICL EVPSRVTVDN QGEKPILVKT PGREKLRITA MLGVLADGRK LPPYIILRGT
YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL EVVWRRRTGA VPRQRGMLIL NGFRCHATDS
VKSSMENMNT DMVIIPGGLT SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK
KPPLGLFLEW IMVAWNSISS ESIVQGFRKC HISSNLEDEG DVLWEIEGEL PKEPPKECGP
ESVAEGD
