ID   POC1A_BOVIN             Reviewed;         407 AA.
AC   Q2TBP4;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=POC1 centriolar protein homolog A;
DE   AltName: Full=WD repeat-containing protein 51A;
GN   Name=POC1A; Synonyms=WDR51A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in centriole assembly and/or
CC       stability and ciliogenesis. Involved in early steps of centriole
CC       duplication, as well as in the later steps of centriole length control.
CC       Acts in concert with POC1B to ensure centriole integrity and proper
CC       mitotic spindle formation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with POC1B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}. Note=Component of both mother and daughter centrioles.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC109862; AAI09863.1; -; mRNA.
DR   RefSeq; NP_001033649.1; NM_001038560.2.
DR   AlphaFoldDB; Q2TBP4; -.
DR   SMR; Q2TBP4; -.
DR   STRING; 9913.ENSBTAP00000001927; -.
DR   PaxDb; Q2TBP4; -.
DR   PRIDE; Q2TBP4; -.
DR   GeneID; 534489; -.
DR   KEGG; bta:534489; -.
DR   CTD; 25886; -.
DR   eggNOG; ENOG502QSVJ; Eukaryota.
DR   HOGENOM; CLU_000288_57_17_1; -.
DR   InParanoid; Q2TBP4; -.
DR   OrthoDB; 1196215at2759; -.
DR   TreeFam; TF324210; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..407
FT                   /note="POC1 centriolar protein homolog A"
FT                   /id="PRO_0000231521"
FT   REPEAT          17..56
FT                   /note="WD 1"
FT   REPEAT          59..98
FT                   /note="WD 2"
FT   REPEAT          101..140
FT                   /note="WD 3"
FT   REPEAT          143..182
FT                   /note="WD 4"
FT   REPEAT          185..224
FT                   /note="WD 5"
FT   REPEAT          227..266
FT                   /note="WD 6"
FT   REPEAT          269..308
FT                   /note="WD 7"
FT   REGION          317..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          369..397
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        340..357
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  45228 MW;  A73AA7CAD0F87113 CRC64;
     MTAHCPEDPS LERHFKGHRD AVTSVDFSLN TKQLASGSMD SCLMVWHMKP QTRAYRFAGH
     KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR AHTATVRSVH FCSDGQSFVT
     ASDDKTVKVW STHRQKFLFS LSQHINWVRC AKFSPDGRLI VSASDDKTVK LWDKTSRECV
     HSYCEHGGFV TYVDFHPSGT CIAAAGMDNT VKVWDVRTHR LLQHYQLHSA AVNALSFHPS
     GNYLVTASSD STLKILDLME GRLLYTLHGH QGPATTVAFS RTGEYFASGG SDEQVMVWKS
     NFDIVDYGEV LRVQRPPATR ASSSGTLPEV DPLVPPGRGR SQESMQSHSQ EPVSVPQSLT
     STLEHIVGQL DVLTQTVSIL EQRLTLTEDK LKQCLENQQL IMQRTTP