ID   PNRC2_CHICK             Reviewed;         141 AA.
AC   Q5ZMB7;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Proline-rich nuclear receptor coactivator 2;
GN   Name=PNRC2; ORFNames=RCJMB04_2j14;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a
CC       bridge between the mRNA decapping complex and the NMD machinery. May
CC       act by targeting the NMD machinery to the P-body and recruiting the
CC       decapping machinery to aberrant mRNAs. Required for UPF1/RENT1
CC       localization to the P-body. Also acts as a nuclear receptor coactivator
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, P-body
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PNRC family. PNRC2 subfamily. {ECO:0000305}.
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DR   EMBL; AJ719467; CAG31126.1; -; mRNA.
DR   RefSeq; NP_001006315.1; NM_001006315.1.
DR   AlphaFoldDB; Q5ZMB7; -.
DR   STRING; 9031.ENSGALP00000039675; -.
DR   PaxDb; Q5ZMB7; -.
DR   GeneID; 419688; -.
DR   KEGG; gga:419688; -.
DR   CTD; 55629; -.
DR   VEuPathDB; HostDB:geneid_419688; -.
DR   eggNOG; ENOG502RZZX; Eukaryota.
DR   InParanoid; Q5ZMB7; -.
DR   OrthoDB; 1570409at2759; -.
DR   PhylomeDB; Q5ZMB7; -.
DR   PRO; PR:Q5ZMB7; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR026780; PNRC1/2.
DR   InterPro; IPR026781; PNRC2.
DR   PANTHER; PTHR15405; PTHR15405; 1.
DR   PANTHER; PTHR15405:SF6; PTHR15405:SF6; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..141
FT                   /note="Proline-rich nuclear receptor coactivator 2"
FT                   /id="PRO_0000058484"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           101..107
FT                   /note="SH3-binding"
FT   COMPBIAS        25..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   141 AA;  16078 MW;  E93DE2EAC46C314D CRC64;
     MVGGERFNIP VPQSRNITKN HQQLKNRQKN KDQNSQMKKT YMKKERGHGC NSLSGAWQAM
     QKAGKNNVHF PCNQNWSPNL SNRNLFFSPQ TNQNYAGAKF SEPPSPSVLP KPPSHWVPVS
     FKPSDKEIMT FQLKTLLKVQ A