AT1B3_BOVIN
ID AT1B3_BOVIN Reviewed; 279 AA.
AC Q3T0C6;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-3;
DE AltName: Full=Sodium/potassium-dependent ATPase subunit beta-3;
DE Short=ATPB-3;
DE AltName: CD_antigen=CD298;
GN Name=ATP1B3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane. The exact function of
CC the beta-3 subunit is not known (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
CC catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an
CC additional regulatory subunit. Interacts with catalytic alpha subunit
CC ATP12A. {ECO:0000250|UniProtKB:Q63377}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:Q63377}; Single-pass type II membrane protein
CC {ECO:0000255}. Basolateral cell membrane
CC {ECO:0000250|UniProtKB:Q63377}; Single-pass type II membrane protein
CC {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:P54709}.
CC Note=Identified by mass spectrometry in melanosome fractions from stage
CC I to stage IV. {ECO:0000250|UniProtKB:P54709}.
CC -!- DOMAIN: The C-terminal lobe folds into an immunoglobulin-like domain
CC and may mediate cell adhesion properties. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000305}.
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DR EMBL; BC102454; AAI02455.1; -; mRNA.
DR RefSeq; NP_001030470.1; NM_001035393.2.
DR AlphaFoldDB; Q3T0C6; -.
DR SMR; Q3T0C6; -.
DR STRING; 9913.ENSBTAP00000018795; -.
DR PaxDb; Q3T0C6; -.
DR PeptideAtlas; Q3T0C6; -.
DR PRIDE; Q3T0C6; -.
DR Ensembl; ENSBTAT00000018795; ENSBTAP00000018795; ENSBTAG00000014140.
DR GeneID; 532844; -.
DR KEGG; bta:532844; -.
DR CTD; 483; -.
DR VEuPathDB; HostDB:ENSBTAG00000014140; -.
DR VGNC; VGNC:26287; ATP1B3.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT01030000234579; -.
DR HOGENOM; CLU_057702_1_1_1; -.
DR InParanoid; Q3T0C6; -.
DR OMA; PKLGKWE; -.
DR OrthoDB; 998086at2759; -.
DR TreeFam; TF314618; -.
DR Reactome; R-BTA-5578775; Ion homeostasis.
DR Reactome; R-BTA-936837; Ion transport by P-type ATPases.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000014140; Expressed in rumen papilla and 103 other tissues.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IBA:GO_Central.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0030007; P:cellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0006883; P:cellular sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:0086009; P:membrane repolarization; IEA:Ensembl.
DR GO; GO:0032781; P:positive regulation of ATP-dependent activity; IEA:Ensembl.
DR GO; GO:1903288; P:positive regulation of potassium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:1901018; P:positive regulation of potassium ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:1903278; P:positive regulation of sodium ion export across plasma membrane; IEA:Ensembl.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.1660; -; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR PANTHER; PTHR11523; PTHR11523; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR TIGRFAMs; TIGR01107; Na_K_ATPase_bet; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium;
KW Sodium transport; Sodium/potassium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..279
FT /note="Sodium/potassium-transporting ATPase subunit beta-3"
FT /id="PRO_0000227885"
FT TOPO_DOM 1..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 186..279
FT /note="immunoglobulin-like"
FT /evidence="ECO:0000250"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 128..144
FT /evidence="ECO:0000250"
FT DISULFID 154..170
FT /evidence="ECO:0000250"
FT DISULFID 191..250
FT /evidence="ECO:0000250"
SQ SEQUENCE 279 AA; 31521 MW; A31276F70A8C8F85 CRC64;
MTKTDKKSFN QSLAEWKLFI YNRTTGEFLG RTAKSWGLIL LFYLVFYGFL AALFSFTMWA
MLQTLNDEVP KYRDQIPSPG LMVFPKPVSA LDFSFSLSDA ESYQGYIDDL KKFLKPYGLE
EQKNLTDCTN GTFFEQKGPE YTACQFPLAL LEACSGVDDP TFGYQEGKPC ILVKMNRIIG
LKPQGEPRIE CTGKSESTAF LSTYPSNGTI DLKYFPYYGK KLHGNYLQPL VAVQVGFGSD
ADVREVMVEC KIDGSPNLKT QNDRDKFLGR VAFKITMHA
