ID   PM2P2_HUMAN             Reviewed;         297 AA.
AC   O95744;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Putative postmeiotic segregation increased 2-like protein 2;
DE   AltName: Full=Postmeiotic segregation increased 2-like protein 14;
DE   AltName: Full=Postmeiotic segregation increased protein 4;
DE   AltName: Full=Putative postmeiotic segregation increased 2 pseudogene 2;
GN   Name=PMS2P2; Synonyms=PMS2L14, PMS2L2, PMS4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Fetal brain;
RX   PubMed=10101297; DOI=10.1093/oxfordjournals.jbchem.a022354;
RA   Kondo E., Horii A., Fukushige S.;
RT   "The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch
RT   repair protein.";
RL   J. Biochem. 125:818-825(1999).
CC   -!- TISSUE SPECIFICITY: Highly expressed in kidney, spleen, adrenal gland,
CC       esophagus, duodenum, colon, bladder, ovary, cerebrum and cerebellum and
CC       to a lower extent in lung, liver, stomach, uterus and pancreas. Not
CC       expressed in heart. {ECO:0000269|PubMed:10101297}.
CC   -!- MISCELLANEOUS: Encoded by one of the numerous copies of postmeiotic
CC       segregation increased 2-like genes scattered in the q11-q22 region of
CC       the chromosome 7.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AB017005; BAA74754.1; -; mRNA.
DR   AlphaFoldDB; O95744; -.
DR   SMR; O95744; -.
DR   BioMuta; HGNC:9127; -.
DR   jPOST; O95744; -.
DR   MassIVE; O95744; -.
DR   MaxQB; O95744; -.
DR   PeptideAtlas; O95744; -.
DR   PRIDE; O95744; -.
DR   GeneCards; PMS2P2; -.
DR   HGNC; HGNC:9127; PMS2P2.
DR   neXtProt; NX_O95744; -.
DR   InParanoid; O95744; -.
DR   PhylomeDB; O95744; -.
DR   Pharos; O95744; Tdark.
DR   PRO; PR:O95744; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; O95744; protein.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IBA:GO_Central.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..297
FT                   /note="Putative postmeiotic segregation increased 2-like
FT                   protein 2"
FT                   /id="PRO_0000311099"
SQ   SEQUENCE   297 AA;  32669 MW;  9D05D86F583B917D CRC64;
     MGESSRKPPT PTPEGPTVSV KQLFSTLPVR HKEFQRNIKK KRACFPFAFC RDCQFLEGSP
     AMLPVQPAKL TEPAKAIKPI DRKSVHQICS GPVVLSLSTA VKKIVGNSLD AGATNIDLKL
     KDYGMDLIEV SGNGCGVEEE NFEGLSLSAL KHHTSKIREF ADLTRVETFG FQGKALSSLC
     ALSDVTISTC HVSAKVGTRL VFDHDGKIIK KTPYPHPRGT TVSVKQLFST LPVRHKEFQR
     NIKKKRACFP FAFCRDCQFL EGSPAMLPVQ PAKLTVTGEL RACRSWKTRE GITEAVG