ID   PLP_RICTY               Reviewed;         282 AA.
AC   Q68WG0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Parvulin-like PPIase;
DE            EC=5.2.1.8;
DE   AltName: Full=Peptidyl-prolyl cis-trans isomerase plp;
DE   AltName: Full=Rotamase plp;
DE   Flags: Precursor;
GN   Name=plp; OrderedLocusNames=RT0565;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PpiC/parvulin rotamase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU04032.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017197; AAU04032.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014419445.1; NC_006142.1.
DR   AlphaFoldDB; Q68WG0; -.
DR   SMR; Q68WG0; -.
DR   STRING; 257363.RT0565; -.
DR   EnsemblBacteria; AAU04032; AAU04032; RT0565.
DR   KEGG; rty:RT0565; -.
DR   eggNOG; COG0760; Bacteria.
DR   HOGENOM; CLU_034646_1_3_5; -.
DR   OMA; YEQAKPT; -.
DR   OrthoDB; 1838755at2; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR000297; PPIase_PpiC.
DR   PROSITE; PS50198; PPIC_PPIASE_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Isomerase; Membrane; Rotamase; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..282
FT                   /note="Parvulin-like PPIase"
FT                   /id="PRO_0000289287"
FT   DOMAIN          138..231
FT                   /note="PpiC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00278"
SQ   SEQUENCE   282 AA;  31596 MW;  26E434297226815D CRC64;
     MKKLSVIFLS VSMLSSIAFC DQDKVVATYK GGEVKESQIM QEFKPQLNLQ SGETIKNFDD
     FPLQDQEKLI KIYVNNLLLK EEVAKSSITS SKEFQEKLEN AKNQLAQQEL LANYIKSNIT
     DKMFDDEYNK YVDNLKGKEQ IKVAHILVKS QKEANTVKTK LSKGGNFNKL AEEFSLDKAT
     ASNGGVIGYI ILNQSGQLVP EFENKAFALK VNEVSTPVKT DFGWHIIKVL EKKPVPIPTK
     KEAKVTIDNI LAAEILKKYI SDLEAKADLK IMLPKANSKT GS