ID   PHZA1_PSEAE             Reviewed;         162 AA.
AC   Q9HWH1; O69752;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Phenazine biosynthesis protein PhzA1 {ECO:0000303|PubMed:11591691};
GN   Name=phzA1 {ECO:0000303|PubMed:11591691}; OrderedLocusNames=PA4210;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=11591691; DOI=10.1128/jb.183.21.6454-6465.2001;
RA   Mavrodi D.V., Bonsall R.F., Delaney S.M., Soule M.J., Phillips G.,
RA   Thomashow L.S.;
RT   "Functional analysis of genes for biosynthesis of pyocyanin and phenazine-
RT   1-carboxamide from Pseudomonas aeruginosa PAO1.";
RL   J. Bacteriol. 183:6454-6465(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [3]
RP   INDUCTION.
RX   PubMed=11544214; DOI=10.1128/jb.183.19.5529-5534.2001;
RA   Whiteley M., Greenberg E.P.;
RT   "Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-
RT   controlled genes.";
RL   J. Bacteriol. 183:5529-5534(2001).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=23129634; DOI=10.1073/pnas.1213901109;
RA   Recinos D.A., Sekedat M.D., Hernandez A., Cohen T.S., Sakhtah H.,
RA   Prince A.S., Price-Whelan A., Dietrich L.E.;
RT   "Redundant phenazine operons in Pseudomonas aeruginosa exhibit environment-
RT   dependent expression and differential roles in pathogenicity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:19420-19425(2012).
CC   -!- FUNCTION: Involved in the biosynthesis of the antibiotic phenazine, a
CC       nitrogen-containing heterocyclic molecule. PhzA1 (operon
CC       phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during
CC       planktonic growth. {ECO:0000269|PubMed:23129634,
CC       ECO:0000305|PubMed:11591691}.
CC   -!- PATHWAY: Antibiotic biosynthesis; phenazine biosynthesis.
CC       {ECO:0000305|PubMed:11591691}.
CC   -!- INDUCTION: Under control of LasR (PubMed:11544214). In liquid cultures
CC       (aerobic), phz1 operon is induced by quinolone signal via 2-heptyl-3-
CC       hydroxy-4-quinolone (PQS) (PubMed:23129634). In biofilm (microaerobic),
CC       phz1 operon is not induced by PQS, because the biosynthesis of PQS by
CC       the monooxygenase PqsH requires molecular oxygen (PubMed:23129634).
CC       {ECO:0000269|PubMed:11544214, ECO:0000269|PubMed:23129634}.
CC   -!- SIMILARITY: Belongs to the PhzA/PhzB family. {ECO:0000305}.
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DR   EMBL; AF005404; AAC64489.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG07597.1; -; Genomic_DNA.
DR   PIR; E83118; E83118.
DR   RefSeq; NP_252899.1; NC_002516.2.
DR   RefSeq; WP_003114729.1; NZ_QZGD01000024.1.
DR   AlphaFoldDB; Q9HWH1; -.
DR   SMR; Q9HWH1; -.
DR   STRING; 287.DR97_3701; -.
DR   PaxDb; Q9HWH1; -.
DR   PRIDE; Q9HWH1; -.
DR   DNASU; 880515; -.
DR   EnsemblBacteria; AAG07597; AAG07597; PA4210.
DR   GeneID; 880515; -.
DR   KEGG; pae:PA4210; -.
DR   PATRIC; fig|208964.12.peg.4411; -.
DR   PseudoCAP; PA4210; -.
DR   HOGENOM; CLU_141345_0_0_6; -.
DR   OMA; RYMAMKG; -.
DR   PhylomeDB; Q9HWH1; -.
DR   BioCyc; PAER208964:G1FZ6-4283-MON; -.
DR   UniPathway; UPA00099; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0002047; P:phenazine biosynthetic process; IDA:PseudoCAP.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR004964; PhzA_PhzB.
DR   Pfam; PF03284; PHZA_PHZB; 1.
DR   SUPFAM; SSF54427; SSF54427; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic biosynthesis; Reference proteome.
FT   CHAIN           1..162
FT                   /note="Phenazine biosynthesis protein PhzA1"
FT                   /id="PRO_0000287798"
FT   CONFLICT        91
FT                   /note="T -> A (in Ref. 1; AAC64489)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   162 AA;  19212 MW;  8B89D65CDEF67198 CRC64;
     MNGQRYRETP LDIERLRRLN RATVERYMAM KGAERLQRHS LFVEDGCAGN WTTESGEPLV
     FRGHESLRRL AEWLERCFPD WEWHNVRIFE TEDPNHFWVE CDGRGKALVP GYPQGYCENH
     YIHSFELENG RIKRNREFMN PIQKLRALGI AVPQIKRDGI PT