PHLA1_RAT
ID PHLA1_RAT Reviewed; 407 AA.
AC Q9QZA1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Pleckstrin homology-like domain family A member 1;
DE AltName: Full=Proline- and glutamine-rich protein;
DE Short=PQ-rich protein;
DE Short=PQR protein;
GN Name=Phlda1; Synonyms=Pqr;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-407, FUNCTION, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RX PubMed=10428057; DOI=10.1046/j.1471-4159.1999.0730612.x;
RA Gomes I., Xiong W., Miki T., Rosner M.R.;
RT "A proline- and glutamine-rich protein promotes apoptosis in neuronal
RT cells.";
RL J. Neurochem. 73:612-622(1999).
CC -!- FUNCTION: Seems to be involved in regulation of apoptosis. May be
CC involved in detachment-mediated programmed cell death. May mediate
CC apoptosis during neuronal development. May be involved in regulation of
CC anti-apoptotic effects of IGF1. May be involved in translational
CC regulation. {ECO:0000269|PubMed:10428057}.
CC -!- SUBUNIT: Interacts with RPL14, EIF3S7 and PABPC4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8WV24}.
CC Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8WV24}. Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q8WV24}. Note=Colocalizes with intracellular
CC vesicles. {ECO:0000250|UniProtKB:Q8WV24}.
CC -!- DEVELOPMENTAL STAGE: Expression increases during embryonal development
CC at embryonic days E11, E15 and E17. {ECO:0000269|PubMed:10428057}.
CC -!- INDUCTION: Induced by FGF in a hippocampal progenitor cell line.
CC Induced by FGF and EGF in a CNS neuronal cell line.
CC {ECO:0000269|PubMed:10428057}.
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DR EMBL; AABR03055997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF192802; AAF07181.1; -; mRNA.
DR AlphaFoldDB; Q9QZA1; -.
DR STRING; 10116.ENSRNOP00000005361; -.
DR PaxDb; Q9QZA1; -.
DR PRIDE; Q9QZA1; -.
DR UCSC; RGD:3836; rat.
DR RGD; 3836; Phlda1.
DR eggNOG; ENOG502RZ5Q; Eukaryota.
DR InParanoid; Q9QZA1; -.
DR PhylomeDB; Q9QZA1; -.
DR Reactome; R-RNO-8854521; Interaction between PHLDA1 and AURKA.
DR PRO; PR:Q9QZA1; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0045210; P:FasL biosynthetic process; ISO:RGD.
DR GO; GO:0021879; P:forebrain neuron differentiation; IEP:RGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:RGD.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042832; PHLA1/2/3.
DR PANTHER; PTHR15478; PTHR15478; 2.
DR SMART; SM00233; PH; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; Cytoplasmic vesicle; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1..407
FT /note="Pleckstrin homology-like domain family A member 1"
FT /id="PRO_0000053899"
FT DOMAIN 149..184
FT /note="PH"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..348
FT /note="15 X 2 AA repeats of P-Q"
FT REGION 354..381
FT /note="11 X 2 AA repeats of P-H"
FT COMPBIAS 46..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..344
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..384
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 45746 MW; E9196AE04A254B3C CRC64;
MRRTPAAERL SELGFPPRRG SQEPPFPLGV TRGWGGWPIE KRCEGPRPVP FSERSAEDGR
EQPAHGSGIL WRVRTRLSLC RDPEPPPPPP PLCLLRVSLL CALRAGGRGS RWSEDSARLL
LLPPAGASGS LKAERSSSTP YAGRMLESSG CKALKEGVLE KRSDGLLQLW KKKCCILTEE
GLLLIPPKQV QHQQQQQQQQ QPGQGTAEPS QPSGPAVTSL EPPAKLKELH FSNMKTVDCV
ERKGKYMYFT VVMAEGKEID FRCPQDQGWN AEITLQMVQY KNRQAILAVK STRQKQQHLV
QQQPPQTQQI QPQPQQPQIQ PQPQPQIQPQ PQPQPQPQPQ PQQQPQPQQL HSYPHPHPHL
YPHPHPHAHS HPHPHPHPHP HQLQHAHQPL HSQPQGHRLL RSTSNSA
