ID   PHK_METCA               Reviewed;         811 AA.
AC   Q608B0;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable phosphoketolase {ECO:0000255|HAMAP-Rule:MF_01403};
DE            EC=4.1.2.- {ECO:0000255|HAMAP-Rule:MF_01403};
GN   OrderedLocusNames=MCA1587;
OS   Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylococcus.
OX   NCBI_TaxID=243233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33009 / NCIMB 11132 / Bath;
RX   PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA   Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA   Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA   Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J.,
RA   Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L.,
RA   Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H.,
RA   Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R.,
RA   Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.;
RT   "Genomic insights into methanotrophy: the complete genome sequence of
RT   Methylococcus capsulatus (Bath).";
RL   PLoS Biol. 2:1616-1628(2004).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01403};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01403}.
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DR   EMBL; AE017282; AAU92125.1; -; Genomic_DNA.
DR   RefSeq; WP_010960853.1; NC_002977.6.
DR   AlphaFoldDB; Q608B0; -.
DR   SMR; Q608B0; -.
DR   STRING; 243233.MCA1587; -.
DR   PRIDE; Q608B0; -.
DR   EnsemblBacteria; AAU92125; AAU92125; MCA1587.
DR   KEGG; mca:MCA1587; -.
DR   eggNOG; COG3957; Bacteria.
DR   HOGENOM; CLU_013954_2_0_6; -.
DR   OMA; EHMCQGF; -.
DR   OrthoDB; 45239at2; -.
DR   Proteomes; UP000006821; Chromosome.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003824; F:catalytic activity; ISS:JCVI.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0009758; P:carbohydrate utilization; ISS:JCVI.
DR   Gene3D; 3.40.50.920; -; 1.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PTHR31273; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome; Thiamine pyrophosphate.
FT   CHAIN           1..811
FT                   /note="Probable phosphoketolase"
FT                   /id="PRO_0000193880"
SQ   SEQUENCE   811 AA;  90976 MW;  76A9A326CC2F44BE CRC64;
     MATQFPLSSE FERLTVYGPT RATVSGTPLD AEEVRKIHAF WRACNYLALG MIYLRGNPLL
     REPLKPEHIK HRLLGHWGSS PNLAFVYTHL NRAIRKHDLD MIFMAGPGHG APGVLGPLYL
     EGSYSEIYPD KDLSEEGLLN FFKQFSFPGG IGSHCTPETP GSIHEGGELG YVLSHACGAA
     FDNPDLIVAA VVGDGEAETG PLATSWHINK FLNPIRDGAV LPILNLNGYK INNPTLLARI
     SHEELENLLR GYGYTPYFVE GSEPESMHQA MAATVDRSIE DIRAAQTEAR ASGIARRPRW
     PMIVLRSPKG WTAPRQIDGH NVEGFWRAHQ VPVADVAKNP EHLKLLEGWM RSYKPEELFD
     AEGCPVAEIR EMAPAGLRRM GLNPHANGGH LKKALRIPNF RNYGIEVAKP GQIEAPNTQP
     LGVFLRDVMK ENAHNFRLFG PDENTSNKLD AVYAAAKKFW IAEYFPEDQD GGELAPDGRV
     MEMLSEHTLE GMLEGYLLTG RHGFLSTYEA FVHVIDSMFN QHAKWLSICN QLSWRQDVAS
     LNLLITSTVW RQDHNGFTHQ DPGFLDVVVN KSADVTRIYL PPDVNSLLSV ADHCLRSQNY
     INVIVSDKQL HLQFMDMDAA IAHCTEGLGI WEWASNDEGQ EPDVVMACAG DIPTLEALAA
     TALLREEFPE LKIRFINVVD LFKLQPESEH PHGLSDKDFD SLFTRDKPVI FNFHGYPWLI
     HRLAYRRTNH ANMHVRGYKE KGNINTPLEL AINNQIDRFS LAIDVIDRIP EIAVSGAHAK
     ARFRKQQIAC RQYAYEHGVD MPEVAGWRWP G