ID   PHIA_ARTBC              Reviewed;         186 AA.
AC   D4AV66;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Cell wall protein phiA {ECO:0000305};
DE   AltName: Full=Allergen Asp f 34 homolog {ECO:0000305};
DE   AltName: Full=Phialide development protein A {ECO:0000250|UniProtKB:Q5ATP7};
DE   Flags: Precursor;
GN   Name=phiA {ECO:0000250|UniProtKB:Q5ATP7}; ORFNames=ARB_00075;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND INDUCTION.
RC   STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000312|Proteomes:UP000008866};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=21919205; DOI=10.1002/pmic.201100234;
RA   Sriranganadane D., Waridel P., Salamin K., Feuermann M., Mignon B.,
RA   Staib P., Neuhaus J.M., Quadroni M., Monod M.;
RT   "Identification of novel secreted proteases during extracellular
RT   proteolysis by dermatophytes at acidic pH.";
RL   Proteomics 11:4422-4433(2011).
CC   -!- FUNCTION: Cell wall protein involved in development of asexual
CC       structures such as phialide and conidium development, and thus required
CC       for spore formation (By similarity). Plays a role as a general stress
CC       protectant produced by the fungus in competition with antagonistic
CC       bacteria (By similarity). {ECO:0000250|UniProtKB:A2R2S8,
CC       ECO:0000250|UniProtKB:Q5ATP7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21919205}. Secreted,
CC       cell wall {ECO:0000250|UniProtKB:Q5ATP7}.
CC   -!- INDUCTION: Expression is down-regulated in presence of human
CC       keratinocytes. {ECO:0000269|PubMed:21247460}.
CC   -!- ALLERGEN: May cause an allergic reaction in human. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the phiA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ABSU01000012; EFE32988.1; -; Genomic_DNA.
DR   RefSeq; XP_003013628.1; XM_003013582.1.
DR   AlphaFoldDB; D4AV66; -.
DR   EnsemblFungi; EFE32988; EFE32988; ARB_00075.
DR   GeneID; 9519907; -.
DR   KEGG; abe:ARB_00075; -.
DR   eggNOG; ENOG502SRG4; Eukaryota.
DR   HOGENOM; CLU_097238_0_0_1; -.
DR   OMA; KPVACKY; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Allergen; Cell wall; Reference proteome; Secreted; Signal; Sporulation.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..186
FT                   /note="Cell wall protein phiA"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000434416"
SQ   SEQUENCE   186 AA;  19809 MW;  2E3C0A774F511674 CRC64;
     MKLLAIISAS LALAGFTTAT PPPQTFSIKA KGNPKVPSAR FDASRSNIFL NYGDSGAVCE
     VKPGCPKPKD AVFYLKDSIL YLYTGSSNPV QKVFLDRSGF GQGKIGYLTG DGQLPSRWEV
     QGWTIDGAGN LKFKGKGLIA CPTSDPKIKS WTVWADLGIA TPGGNKGCLP FTAHTMKTKP
     VACKYT