ID   A4_VAR67                Reviewed;         271 AA.
AC   P0DOP1; P33832;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 7.
DE   RecName: Full=39kDa core protein;
DE            Short=p39;
DE   AltName: Full=Protein A4;
GN   ORFNames=A4L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1666548;
RA   Shchelkunov S.N., Marennikova S.S., Totmenin A.V., Blinov V.M.,
RA   Chizhikov V.E., Gutorov V.V., Safronov P.F., Pozdnyakov S.G.,
RA   Shelukhina E.M., Gashnikov P.V., Anjaparidze O.G., Sandakhchiev L.S.;
RT   "Creation of a clone library of fragments from the natural variola virus
RT   and study of the structural and functional organization of viral genes from
RT   a circle of hosts.";
RL   Dokl. Akad. Nauk SSSR 321:402-406(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Component of the virion core. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with P4A/A10 and its cleaved form 4A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes between the
CC       core and the membrane; might surround the outer core wall like a
CC       palisade (spikes). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Its phosphorylation state is regulated by the F10 kinase and the
CC       H1 phosphatase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A4 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49049.1; -; Genomic_DNA.
DR   EMBL; X67116; CAA47513.1; -; Genomic_DNA.
DR   PIR; E36848; E36848.
DR   RefSeq; NP_042152.1; NC_001611.1.
DR   SMR; P0DOP1; -.
DR   GeneID; 1486531; -.
DR   KEGG; vg:1486531; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR010396; Orthopox_A5.
DR   Pfam; PF06193; Orthopox_A5L; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..271
FT                   /note="39kDa core protein"
FT                   /id="PRO_0000099220"
FT   REGION          80..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  30060 MW;  26252594A34560FA CRC64;
     MDFFNKFSQG LAESSTPKSS IYYSEEKDLD IKKDEAIEIG LKSQESYYQR QLREQLARDN
     MMAASRQPIQ PLQPTIHITP LQVPTPAPTP KPRQQQTNTS SDMSNLFDWL SADDNTQPSS
     LLPALTPINA VQDIISKFNK DQKTTTTPST QPSQTLPTTT CTQQSDGSIS CTTPTVTPPQ
     PPIVATVCTP TPTGGTVCTT AQQNPNPGAT SQQNLDNMAL KDLMSSVEKD MRQLQAETND
     LVTNVYDARE YTRRAIDQIL QLVKGFERFQ K