ID   PFS2_ASPFU              Reviewed;         510 AA.
AC   Q4X1Y0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Polyadenylation factor subunit 2;
GN   Name=pfs2; ORFNames=AFUA_2G08390;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC       mRNAs. Also involved in chromosome segregation where it has a role in
CC       chromosome attachment to the mitotic spindle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000001; EAL93135.1; -; Genomic_DNA.
DR   RefSeq; XP_755173.1; XM_750080.1.
DR   AlphaFoldDB; Q4X1Y0; -.
DR   SMR; Q4X1Y0; -.
DR   STRING; 330879.Q4X1Y0; -.
DR   EnsemblFungi; EAL93135; EAL93135; AFUA_2G08390.
DR   GeneID; 3513214; -.
DR   KEGG; afm:AFUA_2G08390; -.
DR   VEuPathDB; FungiDB:Afu2g08390; -.
DR   eggNOG; KOG0284; Eukaryota.
DR   HOGENOM; CLU_000288_77_1_1; -.
DR   InParanoid; Q4X1Y0; -.
DR   OMA; HHWDVKS; -.
DR   OrthoDB; 604979at2759; -.
DR   PHI-base; PHI:2514; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR045245; Pfs2-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22836; PTHR22836; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromosome partition; mRNA processing; Nucleus; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..510
FT                   /note="Polyadenylation factor subunit 2"
FT                   /id="PRO_0000238496"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          91..130
FT                   /note="WD 2"
FT   REPEAT          133..172
FT                   /note="WD 3"
FT   REPEAT          175..215
FT                   /note="WD 4"
FT   REPEAT          218..258
FT                   /note="WD 5"
FT   REPEAT          288..327
FT                   /note="WD 6"
SQ   SEQUENCE   510 AA;  56077 MW;  56F5FE7EEB18B562 CRC64;
     MLPPLARIHS PADTIPVRHL HQSIGKSKKP ITVVRWTPEG RRLLTGGHTG EFMLWNGTAF
     NFETVMDVRG QKGDIKYWRP NFNNVETIDD AHHDAVRDLA WSPSDTKFLS ASDDTTLKIF
     DFTARTADTV LTGHNWDVKS CDWHPTKGLL VSGSKDHQVK FWDPRTARCL TTLHSHKNTV
     TTTRFSRVNS NLLATSSRDQ TARVFDLRMM RDICILRGHE KPISSLTWHP IHSSLISTGS
     EDGSLYHYLL DEPNLPSGQV PTIAPYDSPD PANTPAQVIY PAHRIQYAHS ATIWSLDWHP
     LGHILASGSK DNFTRFWSRA RPGETSYMKD RFHIGEEAAE AQGTWSRGFG RRQMREEEEQ
     EAQDEAESLV DQKNTTAQSL PGIQIAPPGL GSLQTGSGSL LPGIGAPQPA PQAGMSASMP
     QMDPGRLAAI LSQQNPSQPQ NFPSATGIPG FPMPPAMSGT PPLNIDLAEL QKQLLSQGIS
     PQNFASLAAS LGSAGLPGLQ SSTPDNTYRR