ID   PFDB_METTH              Reviewed;         121 AA.
AC   O26774;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 141.
DE   RecName: Full=Prefoldin subunit beta;
DE   AltName: Full=GimC subunit beta;
GN   Name=pfdB; OrderedLocusNames=MTH_678;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
RN   [2]
RP   CHARACTERIZATION.
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=10581246; DOI=10.1093/emboj/18.23.6730;
RA   Leroux M.R., Fandrich M., Klunker D., Siegers K., Lupas A.N., Brown J.R.,
RA   Schiebel E., Dobson C.M., Hartl F.U.;
RT   "MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin
RT   cofactor GimC/prefoldin.";
RL   EMBO J. 18:6730-6743(1999).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
RX   PubMed=11106732; DOI=10.1016/s0092-8674(00)00165-3;
RA   Siegert R., Leroux M.R., Scheufler C., Hartl F.U., Moarefi I.;
RT   "Structure of the molecular chaperone prefoldin. Unique interaction of
RT   multiple coiled coil tentacles with unfolded proteins.";
RL   Cell 103:621-632(2000).
CC   -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC       proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC       archaeal de novo protein folding.
CC   -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AE000666; AAB85183.1; -; Genomic_DNA.
DR   PIR; C69190; C69190.
DR   RefSeq; WP_010876316.1; NC_000916.1.
DR   PDB; 1FXK; X-ray; 2.30 A; A=5-111, B=6-114.
DR   PDBsum; 1FXK; -.
DR   AlphaFoldDB; O26774; -.
DR   SMR; O26774; -.
DR   STRING; 187420.MTH_678; -.
DR   EnsemblBacteria; AAB85183; AAB85183; MTH_678.
DR   GeneID; 24853819; -.
DR   KEGG; mth:MTH_678; -.
DR   PATRIC; fig|187420.15.peg.659; -.
DR   HOGENOM; CLU_131909_0_1_2; -.
DR   OMA; PPQVQAM; -.
DR   EvolutionaryTrace; O26774; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016272; C:prefoldin complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.370; -; 1.
DR   HAMAP; MF_00307; PfdB; 1.
DR   InterPro; IPR002777; PFD_beta-like.
DR   InterPro; IPR012713; PfdB.
DR   InterPro; IPR009053; Prefoldin.
DR   Pfam; PF01920; Prefoldin_2; 1.
DR   TIGRFAMs; TIGR02338; gimC_beta; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..121
FT                   /note="Prefoldin subunit beta"
FT                   /id="PRO_0000124863"
FT   HELIX           7..47
FT                   /evidence="ECO:0007829|PDB:1FXK"
FT   STRAND          54..58
FT                   /evidence="ECO:0007829|PDB:1FXK"
FT   STRAND          61..65
FT                   /evidence="ECO:0007829|PDB:1FXK"
FT   HELIX           67..107
FT                   /evidence="ECO:0007829|PDB:1FXK"
SQ   SEQUENCE   121 AA;  13863 MW;  B405798F1C976C5A CRC64;
     MELPQNVQHQ LAQFQQLQQQ AQAISVQKQT VEMQINETQK ALEELSRAAD DAEVYKSSGN
     ILIRVAKDEL TEELQEKLET LQLREKTIER QEERVMKKLQ EMQVNIQEAM KGAGINPGMG
     N