ID   PFDA_THEAC              Reviewed;         130 AA.
AC   Q9HJ94;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Prefoldin subunit alpha;
DE   AltName: Full=GimC subunit alpha;
GN   Name=pfdA; OrderedLocusNames=Ta1076;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC       proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC       archaeal de novo protein folding (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC12204.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL445066; CAC12204.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_010901487.1; NC_002578.1.
DR   AlphaFoldDB; Q9HJ94; -.
DR   SMR; Q9HJ94; -.
DR   STRING; 273075.Ta1076m; -.
DR   EnsemblBacteria; CAC12204; CAC12204; CAC12204.
DR   GeneID; 1457075; -.
DR   KEGG; tac:Ta1076; -.
DR   eggNOG; arCOG01341; Archaea.
DR   HOGENOM; CLU_156999_0_0_2; -.
DR   OMA; DQYNTVY; -.
DR   OrthoDB; 136126at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016272; C:prefoldin complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.370; -; 1.
DR   HAMAP; MF_00308; PfdA; 1.
DR   InterPro; IPR011599; PFD_alpha_archaea.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   Pfam; PF02996; Prefoldin; 1.
DR   TIGRFAMs; TIGR00293; TIGR00293; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..130
FT                   /note="Prefoldin subunit alpha"
FT                   /id="PRO_0000153690"
SQ   SEQUENCE   130 AA;  14330 MW;  16E4C5DA96C7A0E5 CRC64;
     MARDVEAQLN YIESLISSVD SQIDTLNKAM IEVQSTIDLL SNGDLASSPE KLISIGSGLF
     AKGNITIDED LIVPIGSGIY VAETKERSVE RLKKNLEDIK ASIQKLLDQR KTLVDQYNTV
     YATEATRNVK