ID   PESC_MONBE              Reviewed;         589 AA.
AC   A9URZ4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=19511;
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154;
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; CH991544; EDQ92012.1; -; Genomic_DNA.
DR   RefSeq; XP_001743298.1; XM_001743246.1.
DR   AlphaFoldDB; A9URZ4; -.
DR   SMR; A9URZ4; -.
DR   STRING; 81824.XP_001743298.1; -.
DR   PRIDE; A9URZ4; -.
DR   EnsemblProtists; EDQ92012; EDQ92012; MONBRDRAFT_19511.
DR   GeneID; 5888647; -.
DR   KEGG; mbr:MONBRDRAFT_19511; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   InParanoid; A9URZ4; -.
DR   OMA; TWIVPHY; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..589
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370468"
FT   DOMAIN          346..440
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          287..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          503..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          261..305
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COILED          520..587
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
SQ   SEQUENCE   589 AA;  67430 MW;  9136EA2A77251B3E CRC64;
     MGRIKKKGEE GTATEYMSRS RAVRKLQLSL ADFRRLCILK GIYPREPPNK KKVTGSTANR
     TYYFVKDINW LLHEPLLQRF RELKTYARRL KKAEAKDQPG VVKAIRRREP KVKVNHLVKE
     RYPSFVDAIR DLDDCLCMLF LFASFPQTGV IRARMVEKCR RLCNEFMLYV VRARALRKVF
     LSIKGIYYQA EIMGQTVTWI APYQFATDVP TDVDFRVMGT FLQFYLTLLG FVNFKLYATL
     GMHYPPQFEA AQSEASETMS KHHRKQAKKT ESRVAQALAD VKAAMDEDLN DEEEELDAQT
     KQEAAPADRD QASFDTFEAM ADPAVDSDMN VPSGQDLEEA AAEADAATRI FQNLYFFLSR
     EVPRYSLEFV IRSFGGNVSW DALDEAEAGP YGVDDPRITH HIVDRPAVSQ TFDGRHYVQP
     QWVYDCINAK ALLPTSTYTL GAVLPPHLSP FVEEGADDYM PPERRAQLAA AKNIHSTDMT
     IDESEAPEEI DDEDIYRKEL EAELRGDDTA EAPEEPKGNT AKRKKTKAEK GKAAEEERKE
     MAKLMMSKRD RTLYNRIVHS KKQKQVEAQK LTARRQQIDK EKSAKKSKK