ID   PESC_LEIMA              Reviewed;         671 AA.
AC   O97209;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=LmjF22.0030, LmjF_04_0810;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin;
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B.G., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; FR796400; CAC22625.1; -; Genomic_DNA.
DR   RefSeq; XP_888589.1; XM_883496.1.
DR   AlphaFoldDB; O97209; -.
DR   STRING; 5664.LmjF.04.0810; -.
DR   EnsemblProtists; CAC22625; CAC22625; LMJF_04_0810.
DR   GeneID; 3684880; -.
DR   KEGG; lma:LMJF_04_0810; -.
DR   VEuPathDB; TriTrypDB:LmjF.04.0810; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_040013500; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_040013800; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   InParanoid; O97209; -.
DR   OMA; MAYCAWE; -.
DR   Proteomes; UP000000542; Chromosome 4.
DR   GO; GO:0005730; C:nucleolus; ISO:GeneDB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..671
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370472"
FT   DOMAIN          317..403
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          552..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          634..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          294..323
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COILED          548..584
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        634..663
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  77290 MW;  9CFDC75C61DF3007 CRC64;
     MVHKKQAWAK RVKKERFKKK FLTRMQATRL LQMESVQFRR LCILKGIYPR ALNRSKQKQS
     GNEKQYYLAR EIKWLVRDQI AEKMMAYRAW EKKVKRAEAM GRSEDLKVLQ TSRVKPRHSL
     VATIKERYPY FIDAIRDVDD AMSMIHLYAF LSPEIKSDTT IEIHHSLTSG LSERAKEVCE
     RWDRYVARAR VLTKGFISIK GYYYEAIVKG ERVRWLCPHE YAHRFPPGIQ QYVMLSFLEF
     YLEMMKFVLF KLESDLARDE ADRLAAEDEE GVTRANAEDF ANGAALAVLD VGANQAQAKA
     VKEAESKRSL MEEELHKVRE LFRGLTFFIS REVPAKHFAL VINACGGRVA TDYVPSNITH
     VVVDRPALPP GMKKHDQLEY VQPQYIFDCL NARLVLPVTG YRIGEELPPH VSPFSVSITN
     SAEDNAAVVQ VKKDHPRIVG YVPARVHEIR KLINPSYSAV DPEGKVAHLE DEYSDEESHV
     AVPEMDMEDD VSLSGDELAE ARRKPAWQEE EVTEEVQRPK LSAFKVKKQR EMNLMNAPTN
     EVVARRRQAL RKAQEKSRQT ETSEARLQRK MSEVKRQEAA TRKMQLQVAR KKAARFYKMV
     SGVVQGTAKK VATLEAKAKH IAEGKLRKTE DGKGLVNKRL EARRQRAEAK GKKLKERKAG
     NPYKKLPKWV Q