ID   PESC_LEIIN              Reviewed;         671 AA.
AC   A4HS78; A4HSC3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=LINJ_04_0810;
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM65151.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; FR796436; CAM65151.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001462964.2; XM_001462927.2.
DR   AlphaFoldDB; A4HS78; -.
DR   SMR; A4HS78; -.
DR   STRING; 5671.XP_001462964.2; -.
DR   GeneID; 5066335; -.
DR   KEGG; lif:LINJ_04_0810; -.
DR   VEuPathDB; TriTrypDB:LINF_040013100; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   InParanoid; A4HS78; -.
DR   OMA; TWIVPHY; -.
DR   Proteomes; UP000008153; Chromosome 4.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..671
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370471"
FT   DOMAIN          317..403
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          552..578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          548..584
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        643..663
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  77171 MW;  C24F61576AA3A4F4 CRC64;
     MAHKKQAWAK RVKKERFKKK FLTRMQATRL LQMESVQFRR LCILKGIYPR ALNRSKQKQS
     GHEKQYYLAR EIKWLVRDQI AEKMMAYRAW EKKVKRAEAM GRSEDLKVLQ SSRVKPRHSL
     VATIKERYPY FIDAIRDVDD AMSMIHLYAF LSPEIKSDTT IEIHHSLTSG MSEKAKEVCE
     RWDRYVARAR VLTKGFISIK GYYYEAIVKG ERVRWLCPHE YAHRFPPGIQ QYVMLSFLEF
     YLEMMKFVLF KLESDLARDE ADRLAAEDEE GVTRANAEDF ANGGALAVLD VGANGAQAKE
     VKEAESKRSL MGEELHKVRE LFRGLTFFIS REVPSKRFAL VINACGGRVA TDYVPSNITH
     VVVDRPALPP GMKKHDQLEY VQPQYIFDCL NARLMLPVTG YRIGEELPPH VSPFSVSITN
     SAEDNAAVEQ VKKDHPRIVG YVPARVHEIR KLINPSYSAV DPEGKVAHLE GEYSDEESHV
     AVPEMDMEDD VSLSGDELAE ARRKPAWQEE EVTEEVQRPK LSAFKVKKQR EMNLMNAPTN
     EVVARRRQAL RKAQEKSRQT ETSEARLQRK MSEVKRQEAA TRKMQLQVAR KKAARFYKMI
     SGVVQGTAKK AATLEAKAKH IAEGKLHKTE DGKGLVNTRL EARRQRAEAK SKKLKERKAG
     NPYKKLPKWV Q