ID   PESC_DROVI              Reviewed;         633 AA.
AC   B4LQD0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=GJ14807;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; CH940649; EDW63380.1; -; Genomic_DNA.
DR   RefSeq; XP_002051225.1; XM_002051189.2.
DR   AlphaFoldDB; B4LQD0; -.
DR   SMR; B4LQD0; -.
DR   STRING; 7244.FBpp0229224; -.
DR   EnsemblMetazoa; FBtr0230732; FBpp0229224; FBgn0202011.
DR   GeneID; 6628802; -.
DR   KEGG; dvi:6628802; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   HOGENOM; CLU_019619_0_0_1; -.
DR   InParanoid; B4LQD0; -.
DR   OMA; TWIVPHY; -.
DR   OrthoDB; 777920at2759; -.
DR   PhylomeDB; B4LQD0; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..633
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370461"
FT   DOMAIN          321..414
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          450..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          593..626
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        453..470
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..528
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        553..567
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         453
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         457
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   633 AA;  74245 MW;  BAB281156CF38A8D CRC64;
     MRRPKKYEAG EATQYISRRA ALRKLQLSLN DFRRLCILKG VYPREPKHRR RAQKGSSDIK
     ILYHAKDIRF LLHEPIVWTL RDYKIFAKKS GRDRAIKDFR NLKRRLAMFP EIKLDHIVKE
     RYPTFIDALK DLDDCLTLLF LFSTFPSLHL IPREQSNLCR RLTIEFLHYV IASKSLRKVF
     ISIKGYYFQA EIKGQKVTWI VPHYYPFKPQ SRQEVDFKVM SIFVEFYTIM LGFTNFRLYH
     GLNLAYPPQF PSNMLQDNAD TLKDESSFVS DRITALNFEL LRTDKVQEDE EEPDIDMELL
     EQDGDSKRII KMKQEAQEVS RLRTLFKGLK FFINREVPRE PLVIIIRSFG GKVSWDSSVF
     SGATYDESDE TITHQIVDRP SLSTQYISRD YIQPQWIFDC VNQRQLLPTN KYFLGEPLPP
     HLSPFVDAKR DTYIPPEEKA LHDPSLIETH AQSEDESEDD AAAEEEDTVE QELLDAQLQR
     AYQQETAEYK KYGGADGVNE DEEDSDEEDF DGEEQESDDD DEEELDEKEK RLLEEKQKMS
     VQSGKVHKVN KRQVHKAEVD EHRLQARMVK PRHRNLFRKL IREKQAKEKE EWLLRKKRRT
     IETDAKEAKK LAKREARKAA AAAAAAAAQL GAK