PESC_DROPS
ID PESC_DROPS Reviewed; 631 AA.
AC Q29NB4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN ORFNames=GA18135;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; CH379060; EAL33428.2; -; Genomic_DNA.
DR RefSeq; XP_001356365.2; XM_001356329.3.
DR AlphaFoldDB; Q29NB4; -.
DR SMR; Q29NB4; -.
DR STRING; 7237.FBpp0280331; -.
DR EnsemblMetazoa; FBtr0281893; FBpp0280331; FBgn0078143.
DR GeneID; 4817364; -.
DR KEGG; dpo:Dpse_GA18135; -.
DR eggNOG; KOG2481; Eukaryota.
DR HOGENOM; CLU_019619_0_0_1; -.
DR InParanoid; Q29NB4; -.
DR OMA; TWIVPHY; -.
DR Proteomes; UP000001819; Chromosome 4.
DR Bgee; FBgn0078143; Expressed in female reproductive system and 3 other tissues.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR Gene3D; 3.40.50.10190; -; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PTHR12221; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW Ribosome biogenesis; rRNA processing.
FT CHAIN 1..631
FT /note="Pescadillo homolog"
FT /id="PRO_0000370458"
FT DOMAIN 321..414
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 428..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 591..631
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 431..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..471
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..522
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 453
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 457
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 631 AA; 74524 MW; DFCACE270525A47F CRC64;
MRRPKKYEAG EATQYISRRA AIRKLQLSLN DFRRLCILKG VYPREPKHRR RAQKGSSEIK
ILYHTKDIRF LLHESIVWTL RDYKIFAKKT SRDRAIKDFR NLKRRLALFP EIKLDHIVKE
RYPTFIDALK DLDDCLTLLF LFSTFPSLHL IPREQSNLCR RLTIEFLHYV IASKSLRKVF
ISIKGYYFQA EIKGQKVTWI MPHYYPFKPQ SRQEVDFKVM SIFVEFYTIL QGFTNFRLFH
GLNLAYPPQF PSSLLQDNED TFKDEASFVS DRIAALNFEL LRTDKVQEDE EEPDIDMELL
EQDGDSKRII KMKQEAQEVS RLRTLFKGLK FFINREVPRE PLVILIRSFG GKVSWDASVF
PGATFAENDE TITHQIVDRP SLSTQYISRD YIQPQWLFDC VNQRQLLPTN DYFLGETLPP
HLSPFVDSKR DSYIPPEEKA LHDPSLIETH EQSEEESEED EAEKEEEEAD QELLDAQLQL
AYQQETAEYK KYGGPDGVNE DEEDLSEEDD EEDDDEEDVD KEDVDEQTKR KQQEKEKMSV
QSGKVHKVNK RQVHKAEVDE HRLQARMVKP RHRNLFRKLI REKQTKEKEE WLLRKKRRNI
DADNKEAKKA AKREARKQAA EAAARAAKLV K
