ID   PESC_DROMO              Reviewed;         631 AA.
AC   B4KID9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=GI18209;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; CH933807; EDW13436.1; -; Genomic_DNA.
DR   RefSeq; XP_002003994.1; XM_002003958.2.
DR   AlphaFoldDB; B4KID9; -.
DR   SMR; B4KID9; -.
DR   STRING; 7230.FBpp0167426; -.
DR   EnsemblMetazoa; FBtr0168934; FBpp0167426; FBgn0140948.
DR   GeneID; 6578072; -.
DR   KEGG; dmo:Dmoj_GI18209; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   HOGENOM; CLU_019619_0_0_1; -.
DR   InParanoid; B4KID9; -.
DR   OMA; TWIVPHY; -.
DR   OrthoDB; 777920at2759; -.
DR   PhylomeDB; B4KID9; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..631
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370456"
FT   DOMAIN          321..414
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          450..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          489..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          510..541
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        453..469
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..522
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..540
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..565
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         453
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         457
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   631 AA;  74288 MW;  383DFE1E7496B5BA CRC64;
     MRRPKKYEAG EATQYISRRA ALRKLQLSLN DFRRLCILKG VYPREPKHRR RAQKGSSEIK
     ILYHTKDIRF LLHEPIVWTL RDYKIFAKKS GRDRAIKDFR NLKRRLALFP EIKLDHIVKE
     RYPTFIDALK DLDDCLTLLF LFSTFPSLHL IPREQSNLCR RLTIEFLHYV IASKSLRKVF
     ISIKGYYFQA EIKGQKVTWI VPHYYPFKPQ SRQEVDFKVM SIFVEFYTIM LGFTNYRLYH
     GLNLAYPPQF PSSMLQDNEE TLKDETSFVS ERIAALNFEL LRTDKVQEDE EEPDIDMELL
     EQDGDSKRII KMKQEAQEIA RLRNLFKGLK FFINREVPRE PLVIIIRSFG GKVSWDSSVF
     SGSTYDESDE TITHQIVDRP SLSTQYISRD YIQPQWVFDC VNQRQLLPTN KYFLGEELPP
     HLSPFVDAKR DTYVPPEEKA LHDPSLIETH AQSDDESDEE EAAQNEDDTV DQELLDAQLQ
     RAYQQETAEY KKYGGPDGVN EDEEDTDDDF DGEQESDEEE EELDEKTKRL QEEKKKMSVQ
     SGKVHKVNKR QLHKAEVDEH RLQARMVKPR HRNLFRKLIR EKQSKEKEEW LLRKKRRNID
     NDTKEAKKLV KREAKKAAAA AAAAASQLGV K