ID   PESC_DROAN              Reviewed;         627 AA.
AC   B3MUX9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=GF21889;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; CH902624; EDV33044.1; -; Genomic_DNA.
DR   RefSeq; XP_001964910.1; XM_001964874.2.
DR   AlphaFoldDB; B3MUX9; -.
DR   SMR; B3MUX9; -.
DR   STRING; 7217.FBpp0125081; -.
DR   EnsemblMetazoa; FBtr0126589; FBpp0125081; FBgn0098889.
DR   GeneID; 6504559; -.
DR   KEGG; dan:6504559; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   HOGENOM; CLU_019619_0_0_1; -.
DR   InParanoid; B3MUX9; -.
DR   OMA; TWIVPHY; -.
DR   OrthoDB; 777920at2759; -.
DR   PhylomeDB; B3MUX9; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..627
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370452"
FT   DOMAIN          321..414
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          436..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          489..562
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          596..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..451
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        452..471
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..520
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        521..537
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        548..562
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..615
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         453
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         457
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   627 AA;  74085 MW;  61202591E027E422 CRC64;
     MRRPKKYESG EATQYISRRA ALRKLQLSLN DFRRLCILKG VYPREPKHRR RAQKGSSEIR
     VLYHTKDIRF LLHEQIVWTL RDYKIFAKKS NRDRAIKDFR NLKRRLALFP EIKLDHIVKE
     RYPTFIDALK DLDDCLTLLF LFSTFPSLHL IPREQSNLCR RLTVEFLHYV IASKSLRKVF
     ISIKGYYFQA EIKGQKVTWI VPHYYPFKPQ SRQEVDFKVM SIFVEFYTIM LGFTNFRLFH
     GLNLAYPPQF PTNMLQDNED TFKDESSFVS DRIAALNFEL LRTDKVQEDE EELDIDMELL
     EQDGDSKRII KMKQEAQEVA RLRTLFKGLK FFINREVPRE PLVIIIRSFG GKVSWDSSIF
     PGSTFDESDE TITHQIVDRP SLATQYISRD YIQPQWLFDC VNQRQLLPTN KYFIGEKLPP
     HLSPFVDSKR DTYIPPEEKA LHDPSLIETH EQSDDDSDEE AAQEEEEAVD QELLDAQLQL
     AYQQETAEYK KYGGPDGVNE DEEDPEEDEE DEDEEEEEEL DEQAKRLKEE KQKMSVQSGK
     VHKVNKRQLH KAEVDEHRLQ ARMVKPRHRN LFRKLIREKQ TKEKEEWLLR KKRRTFEAGE
     KEARKTAKRA ARKEAAAAAA KASKLGK