PESC_DICDI
ID PESC_DICDI Reviewed; 678 AA.
AC Q54HJ2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN ORFNames=DDB_G0289415;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000140; EAL62735.1; -; Genomic_DNA.
DR RefSeq; XP_636241.1; XM_631149.1.
DR AlphaFoldDB; Q54HJ2; -.
DR SMR; Q54HJ2; -.
DR STRING; 44689.DDB0188412; -.
DR PaxDb; Q54HJ2; -.
DR EnsemblProtists; EAL62735; EAL62735; DDB_G0289415.
DR GeneID; 8627131; -.
DR KEGG; ddi:DDB_G0289415; -.
DR dictyBase; DDB_G0289415; -.
DR eggNOG; KOG2481; Eukaryota.
DR HOGENOM; CLU_019619_0_0_1; -.
DR InParanoid; Q54HJ2; -.
DR OMA; TWIVPHY; -.
DR PhylomeDB; Q54HJ2; -.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q54HJ2; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 3.40.50.10190; -; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PTHR12221; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..678
FT /note="Pescadillo homolog"
FT /id="PRO_0000370467"
FT DOMAIN 352..442
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 265..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 581..640
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 265..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..572
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 678 AA; 78454 MW; B07B9F633666345D CRC64;
MGGIKKFKKG EKGENLKFIT RNEAVKKLQI SLKIFRKLCI LKGIHPRDPK KKFKGKHKTY
YYSKDIKYLQ NEKVLEIIRA RKVFKDREKK LINKKQFGAL KNLKENRPMI TLDHIIKERY
PTFQDALKDL DDCLSLIHLF ANMDASAKVR ENQILACERL AREFQYYIIQ SKSLRKVFVS
VKGVYYQADV MGETITWITP LNYLSKKEKE VDYGVMISFL EFYQALMKFV NYRLFTSIGL
TYPPTIDDAK LRKCDSLINI FESKPQQQTK TNNTTKKSKS TTAAAAATTP VDPKLKKLEE
KISKINSKEE KEIKEQIVEE DTNMLQVNSS GISKDFEDLV GNESDNIPKI MDVTTLFKGF
HFYISREVPR HMLEFVILSF GGRVSFPGSG DKVKEVNQSI THQIVDRSNS VKVHNTREYI
QPQWVFDSVN SKLLLPYSEY TIGVIPPAHL SPFVEYEEDS YIPARKQALD ALINSKEFAD
AKINTNAEQD DDNDNDNDNR KQVDSDGESD DEDDEDLEHL ETRYTEELRK EQSKKRKSSE
VDDDDEEEED GEEDGEEEEE EEDGEEESES ESESEQVAKP VLTKKQRDEL NKQKQAEEDT
KLAELMIRKK DKWIYNKVKE TNQQRATANQ TLLEKRNKVE SGKDVNGNVK VAPQPKKPAP
LVKKSQQKQQ QASKKQKK
