ID   PESC_CULQU              Reviewed;         607 AA.
AC   B0WD26;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=CPIJ004969;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; DS231893; EDS44161.1; -; Genomic_DNA.
DR   RefSeq; XP_001846610.1; XM_001846558.1.
DR   AlphaFoldDB; B0WD26; -.
DR   SMR; B0WD26; -.
DR   STRING; 7176.CPIJ004969-PA; -.
DR   PRIDE; B0WD26; -.
DR   GeneID; 6036573; -.
DR   KEGG; cqu:CpipJ_CPIJ004969; -.
DR   VEuPathDB; VectorBase:CPIJ004969; -.
DR   VEuPathDB; VectorBase:CQUJHB001416; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   HOGENOM; CLU_019619_0_0_1; -.
DR   InParanoid; B0WD26; -.
DR   OMA; TWIVPHY; -.
DR   OrthoDB; 777920at2759; -.
DR   PhylomeDB; B0WD26; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..607
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370451"
FT   DOMAIN          320..413
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          486..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..509
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..552
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        567..607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   607 AA;  71088 MW;  EC08E4284085152C CRC64;
     MVKRNHKFQS GEGAQYLTRK AAMRKLQLSM QDFRRLCILK GIYPREPKHR AIAQRGSTDI
     KILYHKKDIT FLLHEPIVWT LRDRKIFNRR IAAAKGKGNN LLKNVRMANY PEIKLDHIIK
     ERFPTFVDAI KELDDCMTLL FLFSTFPAMK TVTRDITSMA RRLSIEFMHY CIASKALRKV
     FVSIKGYYFQ AEIKGELVTW IVPHYYPYQP QRKEYVDFKI MKSFADFFTV MAGFVNFRLY
     NSINLVYPPQ FSVSLDSEES RSNEDTFISE RIAALNSDLL RSDQMGTEEE DDQIDLDLLD
     GDKDSEQVRK LREDAVSLNK LKNLFKGLKF FINREVPREP LVFILRCFGG RASWDRNLFV
     GATFDESDET ITHQIVDRPS LPKQYISRDY VQPQWIFDCV NQRKLLPVNK YLIGAVLPPH
     LSPFNRDDAI YVPPEEAALR DGVELDAGAR NGEERISDDE DEDAEQRQQV QLDYALVKAF
     REEKTEALNS GALEEAPEEE DDDEEAPEED EQTKQKNEKK KKMAVVSGKI FKENPSEQKK
     LTKQEEALRA RMVKSRHKKL YRKMLEKQKK QTKEANLLKE KRQQIDKKQR VEQTQKRKTQ
     RKEILAK