PESC_COCIM
ID PESC_COCIM Reviewed; 688 AA.
AC Q1DLJ4; J3K1M2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN Name=NOP7 {ECO:0000255|HAMAP-Rule:MF_03028}; ORFNames=CIMG_08819;
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=RS;
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; GG704913; EAS30073.3; -; Genomic_DNA.
DR RefSeq; XP_001241656.1; XM_001241655.2.
DR AlphaFoldDB; Q1DLJ4; -.
DR SMR; Q1DLJ4; -.
DR STRING; 246410.Q1DLJ4; -.
DR EnsemblFungi; EAS30073; EAS30073; CIMG_08819.
DR GeneID; 4559787; -.
DR KEGG; cim:CIMG_08819; -.
DR VEuPathDB; FungiDB:CIMG_08819; -.
DR InParanoid; Q1DLJ4; -.
DR OMA; TWIVPHY; -.
DR OrthoDB; 777920at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.10190; -; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PTHR12221; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..688
FT /note="Pescadillo homolog"
FT /id="PRO_0000370487"
FT DOMAIN 351..470
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 411..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 496..536
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COILED 627..686
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 503..521
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..566
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 77417 MW; F4801559E90C5E01 CRC64;
MAKIKKKGTS GAAKNYITRT QAVRKLQISL PDFRRLCIFK GIYPREPRNK KKASKTSTPS
TTFYYTRDIQ YLLHEPLLKR FRDQKALSKK IARSLGRGDV GDAARLEKNN APKITLDHIV
KERYPTFIDA LRDLDDALSL LFLFANLPST ANVPPKTIAL CQRLCHEFQH YLIATNSLRK
SFLSIKGIYY QATIQGQDIL WLVPYRFVQQ VTGDVDYRIM ATFVEFYTTL LGFVNFRLYT
SIGLVYPPKF DSRSDERGAE LAAFTLEGRK VGEMQKAISS EPQTNGQLAK SDSAANDIQA
KVDNILKETT RNNEPDDEAV DVEDNVDAID KFETTAPEAD TLPQPQMSGN EVASLFASFT
FFISREAPRG PLEFLLRAFG CKRVGWDAVL GEGAFTHDET DPRITHQIVD RPPLPESALP
PLPQNPGEGA EKAPRVRPGT RMPGRMYIQP QWVWDCVNEG KLLRHDLYAP GATLPPHLSP
WVKASKGGYD PRLSLAEQES DGEAERQAEE ENEEEESEVE GLSMDKEMVE TENSEAGESD
EESVDGGMDV DIPGSDDEEE ESEEDNALRE LGGSDEAADV QSESEDDEEA ARNQHQMELE
AEAAGLPFTG ADGTGTSSKK SKKQKPLAKK HAAQKKKEQE ELERQKMMMS RKKRKLLDKM
LYSNKKKDEE AEKLRRKRRK IEQGTKGR
