ID   PESC_CHAGB              Reviewed;         660 AA.
AC   Q2HCV1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE   AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   Name=NOP7 {ECO:0000255|HAMAP-Rule:MF_03028}; ORFNames=CHGG_01953;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; CH408029; EAQ93718.1; -; Genomic_DNA.
DR   RefSeq; XP_001221174.1; XM_001221173.1.
DR   AlphaFoldDB; Q2HCV1; -.
DR   SMR; Q2HCV1; -.
DR   STRING; 38033.XP_001221174.1; -.
DR   EnsemblFungi; EAQ93718; EAQ93718; CHGG_01953.
DR   GeneID; 4387482; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   HOGENOM; CLU_019619_1_1_1; -.
DR   InParanoid; Q2HCV1; -.
DR   OMA; TWIVPHY; -.
DR   OrthoDB; 777920at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..660
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370486"
FT   DOMAIN          360..476
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          313..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          501..659
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        507..564
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..633
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  74742 MW;  9F5EFF1585F34BE7 CRC64;
     MGKLKKKGQS GQAKNYITRT QAVKKLQLSL PDFRKLCIWK GIYPREPRSR KKVSKSATAS
     TTFYYTKDIQ YLLHEPLLQK FRDQKVLEKK ISRALGRGDV GDAARLERNA ARPDKTGKPR
     YTLNHVIRER YPTFIDALRD LDDCLSMLFL FANLPSTTAV PAKMIARCER LCLEFEHYLI
     TSHSLRKSFL SIKGIYYQAS IQGEDILWLV PYKFNQRVVG DVDFRIMGTF VEFYMTLLGF
     VNYRLYTAVG LKYPPKFDQL KDDQGAELGA FALEGVNIAT NDDTKAITNG EAEHGPDPKV
     QAEVDKIVQQ LRVESDDKAS EEGPADDVEG EEKPSDAIDK FEPVAPGGDV LPQPSYSSSD
     PAQLFSRLTF FLSRETPRQS LEFILRAFGC KRIGWDSVLG EGSFTTDESD PSITHQIVDR
     PVVQAAMNEE GDGEDNQTSQ KVGPNHRYPG RLYVQPQWVW DSVNDEELKS PELYGPGAAL
     PPHLSPFVKP TQGQYDPTIP LEEQQSEGEA IDAELEDANE EAGEESDVEN DMDVASDEDE
     EEEDEEEFDG VSVSEEEEGS EDEEESATLQ RQRELEAEIS GKSVKGDKKM DAKTKAKLEA
     KKALERKKKS EAEDLERAKG MLSKKKRKLF EQMQYTNNKK SAEDLKLRQK RRRLEKEKKA