ID   PESC_CAEEL              Reviewed;         531 AA.
AC   Q95Y89;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE   AltName: Full=Lipid depleted protein 7 {ECO:0000255|HAMAP-Rule:MF_03028};
GN   Name=lpd-7 {ECO:0000255|HAMAP-Rule:MF_03028}; ORFNames=R13A5.12;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; FO080424; CCD63607.1; -; Genomic_DNA.
DR   RefSeq; NP_498661.1; NM_066260.3.
DR   AlphaFoldDB; Q95Y89; -.
DR   SMR; Q95Y89; -.
DR   BioGRID; 41280; 7.
DR   DIP; DIP-24882N; -.
DR   STRING; 6239.R13A5.12; -.
DR   EPD; Q95Y89; -.
DR   PaxDb; Q95Y89; -.
DR   PeptideAtlas; Q95Y89; -.
DR   EnsemblMetazoa; R13A5.12.1; R13A5.12.1; WBGene00003063.
DR   GeneID; 176072; -.
DR   KEGG; cel:CELE_R13A5.12; -.
DR   UCSC; R13A5.12.1; c. elegans.
DR   CTD; 176072; -.
DR   WormBase; R13A5.12; CE21123; WBGene00003063; lpd-7.
DR   eggNOG; KOG2481; Eukaryota.
DR   GeneTree; ENSGT00390000002626; -.
DR   HOGENOM; CLU_019619_0_0_1; -.
DR   InParanoid; Q95Y89; -.
DR   OMA; TWIVPHY; -.
DR   OrthoDB; 777920at2759; -.
DR   PhylomeDB; Q95Y89; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q95Y89; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00003063; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019915; P:lipid storage; IMP:WormBase.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..531
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370466"
FT   DOMAIN          309..398
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
SQ   SEQUENCE   531 AA;  61626 MW;  398F50BEC3C7343A CRC64;
     MKDRFKQKYT AGAAVAYMSR KQALKKLQLT LKDFRRLCII KGIYPHEPAH KKQANKGSTA
     NKVFYYRKDI NFLAHEPIIN KFRDYKVFLR KLNHLKAKKE EDKLKKLYEN KPVYSLDTIV
     KERFPTFGSA LRDMDDALSL CFTFAMLPHT RVLKEGMIDS CRKLTAEFMH YVIESQSLRN
     TFISIKGIYY QAEVHGEKIT WVVPHERGLP HVTDVDFTVL VTFVEFYIAM LGFVNFKLYQ
     DIGLFYPPQI GQVVKTDEME TEEYKEKVYS LAKPLAKRKD VEQAEDDEPL DLLGEDSDAL
     AQKVREAKSI KTMFKGCVFY LNRECPKEAL TFIIRNGGGI VGWEGGPTDL KADSKNISHH
     VVDRPMDKLE VNRLYVQPQW VFDCLNARRK LPTERYMPGV ALPPHFSPFT SEKAGDYIPF
     ERLEELRSMG KDVSDLEAAI PKTMDELPMR RKEVKPEKPK GIHIAVGQMH KKSKEKFHET
     VEKGQELKMR ELMISKKHQR VYHSMKTTFK RNRNDALKLK KKAKLAKATE A