ID   PESC_BRUMA              Reviewed;         535 AA.
AC   A8QHQ0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=Bm1_57380;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA   Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA   Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA   Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA   Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA   Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA   Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA   Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDP28218.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DS239957; EDP28218.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001902934.1; XM_001902899.1.
DR   AlphaFoldDB; A8QHQ0; -.
DR   SMR; A8QHQ0; -.
DR   STRING; 6279.A8QHQ0; -.
DR   PRIDE; A8QHQ0; -.
DR   GeneID; 6106356; -.
DR   CTD; 6106356; -.
DR   WormBase; Bm13949; BM24668; WBGene00234210; Bma-lpd-7.
DR   InParanoid; A8QHQ0; -.
DR   OrthoDB; 777920at2759; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..535
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370464"
FT   DOMAIN          314..406
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
SQ   SEQUENCE   535 AA;  62896 MW;  26AA0A0694A4D98B CRC64;
     MRHFTYHSDV VVWQYIFESG AATNYITRGR ALKKLQLSLK DFRRLCILKG VYPHEPLHKK
     KVNKGSTENR VYYYAKDINF LASEPIIRKF REYKIFLRKL TTAKAKRDEE RIKTLYENRP
     EYQLDHIVKE RYPTFESALR DLDDALCLLF AFAVLPHTKI ITSSLVASSR RLTAEFNHYI
     IESNSLNKVF VSIKGIYYEA EVMGERVTWI VGHDRGMGHV SEVDFSVMAT FAEFYVTMLE
     FVNFRLYQSV GLFYPPKLAF KSDKLEDDDQ AEEGRVYSLA CPLSKFENYE EQIDASIGDE
     VDNVLNEKLC DVEKRKQLFA NYRFWLNREV PKDVLAIIIR SCGGLVSWEN CPAAQYYEND
     AQITHQIVDR PLLDSHKNIS RCYVQPQWVF DSFNRRSCLS IKKYLPGAIL PPHLSPFSSD
     YDTYEEQLNQ LRLLSKASAN VTNRMETEAE NKVQERKKIQ KEKEVPIINV NKGRMHKENL
     QKKLNEKGHE LKLREMLIPK KRRRVYSKIK RGIKRRVHEE KKLNEKRLKM LKAAD