ID   PESC_ASPFC              Reviewed;         675 AA.
AC   B0Y612;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE   AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   Name=nop7; ORFNames=AFUB_065290;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC       ytm1. The complex is held together by erb1, which interacts with nop7
CC       via its N-terminal domain and with ytm1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS499598; EDP50197.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0Y612; -.
DR   SMR; B0Y612; -.
DR   EnsemblFungi; EDP50197; EDP50197; AFUB_065290.
DR   VEuPathDB; FungiDB:AFUB_065290; -.
DR   HOGENOM; CLU_019619_1_1_1; -.
DR   PhylomeDB; B0Y612; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..675
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370479"
FT   DOMAIN          352..471
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          309..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          475..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          551..675
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        501..516
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..577
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..675
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   675 AA;  75396 MW;  CD8A83F699DA7E91 CRC64;
     MGKIKKKGTS GQAKNYITRT QAVRKLQISL PDFRRLCIFK GIYPREPRNK KKASKTSTPN
     TTFYYTKDIQ YLLHEPLLRK FREQKAVAKK IARSLGRGEV GDAARLEKNH APKLTLDHVI
     KERYPTFIDA LRDLDDALSL LFLFANLPST AHVPPKTIAL CQRLCHEFQH YLITTNSLRK
     SFLSIKGIYY QATIQGQDIL WLVPYRFVQR VNGDVDYRIM ATFVDFYTTL LGFVNFRLYS
     SIGLRYPPKF DTRSDENGAE LAAFTLEGRG VGDAPKAIEA GNTQATTSTN NKEVSKEIQA
     KVDNVIKSAG LDEAKEEPAA ETTEESSETI DKFEPAAPEA DTLPQPDLSG NEAGSLFAPF
     TFYISREAPR APLEFILRAF GCKRIGWDAV LGDGAFTHDE TDTRITHQIV DRPQLPESSL
     PAIPAASKDG SDAVQKVKPG TRIPGRTYVQ PQWVWDCINE GRLVRPDLYA PGATLPPHLS
     PWVKPSRGGY DPKASLAEQE EEGEAELDED SDEEMEEATS DKKAEAKADV GSESEDEDES
     VDGGMDVAGT DDDESESEDE EEDFDGFEEE AASESEDEEE AARTQHQKEL EAEAAGLPFS
     SNGATSDGSK KKASQAKKIA AKKRKEEEEL ERQKMMMSRK KRKLLEKMIY SNKKQSEEAA
     KLRSKRRKLE KGAAK