PESC_ASPCL
ID PESC_ASPCL Reviewed; 680 AA.
AC A1CHD1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN Name=nop7; ORFNames=ACLA_047550;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; DS027054; EAW10286.1; -; Genomic_DNA.
DR RefSeq; XP_001271712.1; XM_001271711.1.
DR AlphaFoldDB; A1CHD1; -.
DR SMR; A1CHD1; -.
DR STRING; 5057.CADACLAP00004609; -.
DR EnsemblFungi; EAW10286; EAW10286; ACLA_047550.
DR GeneID; 4704232; -.
DR KEGG; act:ACLA_047550; -.
DR VEuPathDB; FungiDB:ACLA_047550; -.
DR eggNOG; KOG2481; Eukaryota.
DR HOGENOM; CLU_019619_1_1_1; -.
DR OMA; TWIVPHY; -.
DR OrthoDB; 777920at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.10190; -; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PTHR12221; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..680
FT /note="Pescadillo homolog"
FT /id="PRO_0000370478"
FT DOMAIN 351..470
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 310..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 496..523
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COILED 613..680
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 316..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..516
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..582
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 76071 MW; 3D9944F8F546DE9C CRC64;
MGKIKKKGTS GQAKNYITRT QAVRKLQISL PDFRRLCIFK GIYPREPRSK KKASKTSTPN
TTFYYTKDIQ YLLHEPLLRK FRDQKAVAKK IARSLGRGEV GDAARLEKNH APKLTLDHVI
KERYPTFIDA LRDLDDALSL LFLFANLPSD AHVPPKTIAL CQRLCHEFQH YLITTNSLRK
SFLSIKGIYY QATIQGQDIM WLVPYRFVQR VNGDVDYRIM ATFVDFYTTL LGFVNFRLYS
SIGLRYPPKF DTRSDENGAE LAAFTLEGRA VGDVPKAIEA GHTQRSSSAN KEVSRDIQAK
VDKVIKSAGL DQAKDEQTAE TTEESSDTID KFEPAAPEAD TLAQPDLSGS QAGSLFAPFT
FYISREAPRA PLEFLLRAFG CKRIGWDAVL GDGAFTNDET DPRITHQIVD RPQLPESSLP
AIPAAAEEDS GAVQKVKPGT RIPGRTYVQP QWVWDCINEG KLVRPDLYSP GATLPPHLSP
WVKPSRGGYD PRASLAEQEE EGEAEMAEDS DEEMEEAADE KSKTASKDEA ESESEEDDDD
ESVDGGMDVA GTDDDESESE SEEEDEDFGG FEDDEAASES EDEEEVARTQ HQKELEAEAA
GLPFSSNGAT SDASKKKASQ AKKIAAKKRK EEEEIERQKM MMSRKKRKLL EKMMYSNKKQ
SEEAAKLRSK RRKLEKGAAK
