ID   PESC_AJECN              Reviewed;         723 AA.
AC   A6RBB0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE   AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   Name=NOP7 {ECO:0000255|HAMAP-Rule:MF_03028}; ORFNames=HCAG_06248;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDN10445.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CH476661; EDN10445.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001538643.1; XM_001538593.1.
DR   AlphaFoldDB; A6RBB0; -.
DR   SMR; A6RBB0; -.
DR   STRING; 339724.A6RBB0; -.
DR   EnsemblFungi; EDN10445; EDN10445; HCAG_06248.
DR   GeneID; 5444824; -.
DR   KEGG; aje:HCAG_06248; -.
DR   HOGENOM; CLU_019619_1_1_1; -.
DR   OrthoDB; 777920at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..723
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370476"
FT   DOMAIN          380..497
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          440..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          501..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          522..551
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COILED          656..723
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        529..548
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        590..619
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        666..723
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  81815 MW;  F7E512ADC8C298CC CRC64;
     MAGRLREERK YRQKNRGLVQ ERIRLSLVVW ESRKQGTSGQ AKNFITRTQA VRKLQISLPD
     FRRLCIFKGI YPREPRNKKK ASKAATPSTT FYYTRDIQYL LHEPLLKKFR EQKALSKKIA
     RALGRGEVGN AARLEKNNAP KLSLDHIIKE RYPTFIDALR DLDDALSLLF LFANLPSTTS
     VPAKTITLCQ RLCHEFQHYL IATNSLRKSF LSIKGIYYQA TILGQDIMWL VPYRFVQRVT
     GDVDYRIMGT FVEFYTTLLG FVNYKLYTSI GLVYPPKFDK SSDERGAELA AFTLEGRYFG
     EAHKAIETSR QPNGSAEKAA TTSKELQAKV DNILEKTQLD TDPTDQSTED QEENIEAIDK
     FEPIAPEADS LPQPQISGDE AGSLFATFTF YISREAPRAP LEFLLRSFGC KRIGWDSVLG
     DGAFTHDELD ARITHQIVDR PQLPQASLPP LPKNPEDGTE AAPRPGTRVP GRTYIQPQWV
     WDCINEGKLL RPDLYAPGAT LPPHLSPWVK PSERGYDPRA SLADQEEEGE AERAAEAEEY
     ENDEQEESGE ESTKSKQSKE LLANLARDSG DENTSGDESV NGGMDIAMAE DTDESSDDGD
     GADKFEGFDQ DEDMSSESED EEEKARSQHQ KELEAEAAGL PFSASSQAES GTIRGKKQQA
     PLAKKRAAQK KKEEEELERQ KMMMSRKKRK LLDKMIYSNK KQDAEAEKLR QKRRKIEQGL
     NKK