ID   PER_PERAM               Reviewed;         893 AA.
AC   Q25637;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Period circadian protein;
GN   Name=per;
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Head, and Thorax;
RA   Reppert S.M.;
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE OF 270-609.
RC   TISSUE=Head, and Thorax;
RX   PubMed=7946353; DOI=10.1016/0896-6273(94)90054-x;
RA   Reppert S.M., Tsai T., Roca A.L., Sauman I.;
RT   "Cloning of a structural and functional homolog of the circadian clock gene
RT   period from the giant silkmoth Antheraea pernyi.";
RL   Neuron 13:1167-1176(1994).
CC   -!- FUNCTION: Involved in the generation of biological rhythms. The
CC       biological cycle depends on the rhythmic formation and nuclear
CC       localization of the tim-per complex. Light induces the degradation of
CC       tim, which promotes elimination of per. Nuclear activity of the
CC       heterodimer coordinatively regulates per and tim transcription negative
CC       feedback loop. Behaves as a negative element in circadian
CC       transcriptional loop. Does not appear to bind DNA, suggesting indirect
CC       transcriptional inhibition (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with timeless (TIM); the complex then
CC       translocates into the nucleus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Nuclear at specific periods of the
CC       day. Interaction with TIM is required for nuclear localization (By
CC       similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated with a circadian rhythmicity. {ECO:0000250}.
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DR   EMBL; U12772; AAA64677.2; -; mRNA.
DR   AlphaFoldDB; Q25637; -.
DR   SMR; Q25637; -.
DR   PRIDE; Q25637; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd00130; PAS; 2.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   Pfam; PF00989; PAS; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55785; SSF55785; 2.
DR   PROSITE; PS50112; PAS; 2.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Nucleus; Phosphoprotein; Repeat.
FT   CHAIN           1..893
FT                   /note="Period circadian protein"
FT                   /id="PRO_0000162623"
FT   DOMAIN          228..371
FT                   /note="PAS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DOMAIN          390..493
FT                   /note="PAS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          592..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          645..716
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          731..751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          784..803
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           66..77
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        8..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..713
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   893 AA;  97174 MW;  28AA2AA54E4DA61F CRC64;
     MEETATHNTK ISDSAYSNSS NSQSQRSSGS SKSRHSNSSG SSGYCGHGSS IQGSSNEPFP
     QPSVTKRNKD KEHKKKKLKS SVTTAATATV TSVVTTVSEY TEHENGTSHM SLGVSGTVVP
     LSGTVAEETE ITEAGSEGSV ISSHAGVALG AAGVVPATTP GPENEAHQMA SLTQTLNSIK
     KMKKMKDLST DIPEETEGHS FSLPMVAEEK EEHIRNSFDA EPPAHNEGEF CVVVSMQDGV
     VVFTTPSITD VVGFPKDMWL GRSFIDFVHP RDRTAFANHI TSGVITPLSN SNPKGGSHPG
     KNSFYCCLRR YRGLKSTGYG VTEKEVSYLP FQLNMTFREL LPHSNPLEVE GNTSPESVPG
     GCNSMFLVIT AKLICSAYKH AGETCASPKF VTRHLATCKL NYVDPECMPY LGYLPHEMLG
     NSVLDFYHPE DLPFLKEVYQ IVMQENGAPF RSKPYRFRSH NGGYILLETE WSSFVNPWSK
     KLEFVVGQHR VLKGPENADV FMAPVEDDTL QISEEVLKES KIIQEEIRSL LSEMVKNNGH
     LEKQQMSKRC RDLATFMESL MDDITKPDLK LELPQEEHSF SEHDSVMLGE ISPHHDYYDS
     KSSTETPPSY NQLNYNDNIQ RFFESKPKTT LSDESGESKI EANRSLMSTD EEGKSGPAAD
     SSLGSSNRKC CSPVNGSGSG SGSGHSSGSA GIGGSAESRR DTSATNTSHG SYKPPLLTEA
     LLCRHNEDME KKMVQKHREQ RNKGSERESK LKKCVHDKLL QEQCHGVKRS GSHSWEGEVY
     KASKHPHVEG GKELNPGSGG SGGGGVTSGL SQCLGVAATG KQYSGVGSVP PIFQGGTNVN
     LWPPFSVTVT PLQPTPPCST HGFATNNIPT PPHMASMIPV YYIEKRAPNF KNN